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Kimidinomycin, a new antibiotic against Mycobacterium avium complex, produced by Streptomyces sp. KKTA-0263

The Journal of Antibiotics volume 75, pages 72–76 (2022)Cite this article

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Abstract

During our screening for antibiotics against Mycobacterium avium complex (MAC) with a mass spectrometry network-based indexing approach, a new compound named kimidinomycin was isolated from the culture broth of Streptomyces sp. KKTA-0263 by solvent extraction, HP20 column chromatography, and preparative HPLC. From the structural elucidation, the compound possesses a 38-membered macrolide structure with an N-methylguanidyl group at the terminal side chain. The compound exhibited antimycobacterial activity against M. avium, M. intracellulare, M. smegmatis, and M. bovis BCG with respective MIC values of 12.5, 0.78, 12.5, and 25.0 µg ml−1.

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Acknowledgements

We express our thanks to Ms. Noriko Sato and Dr. Kenichiro Nagai, School of Pharmacy, Kitasato University for the instrumental measurements. This work was supported by JSPS KAKENHI Grant Number 15K07867 (NK) from the Ministry of Education, Culture, Sport, Science, and Technology, Japan.

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Authors and Affiliations

  1. Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Ayumi Hikima, Hiroshi Tomoda & Nobuhiro Koyama

  2. Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan

    Shumpei Asamizu & Hiroyasu Onaka

  3. RIKEN SPring-8 Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan

    Huiping Zhang

  4. Drug Discovery Laboratory, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Hiroshi Tomoda

  5. Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Nobuhiro Koyama

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  1. Ayumi Hikima
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Correspondence to Hiroshi Tomoda or Nobuhiro Koyama.

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Hikima, A., Asamizu, S., Onaka, H. et al. Kimidinomycin, a new antibiotic against Mycobacterium avium complex, produced by Streptomyces sp. KKTA-0263. J Antibiot 75, 72–76 (2022). https://doi.org/10.1038/s41429-021-00494-3

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