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Molecular targets for therapy

RNA methylation in hematological malignancies and its interactions with other epigenetic modifications

Leukemia volume 35, pages 1243–1257 (2021)Cite this article

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Abstract

Hematological malignancies are a class of malignant neoplasms attributed to abnormal differentiation of hematopoietic stem cells (HSCs). The systemic involvement, poor prognosis, chemotherapy resistance, and recurrence common in hematological malignancies urge researchers to look for novel treatment targets and mechanisms. In recent years, epigenetic abnormalities have been shown to play a vital role in tumorigenesis and progression in hematological malignancies. In addition to DNA methylation and histone modifications, which are most studied, RNA methylation has become increasingly significant. In this review, we elaborate recent advances in the understanding of RNA modification in the pathogenesis, diagnosis and molecular targeted therapies of hematological malignancies and discuss its intricate interactions with other epigenetic modifications, including DNA methylation, histone modifications and noncoding RNAs.

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Fig. 1: The mechanism of m6A RNA methylation.
Fig. 2: The functions of m6A regulators in leukemia.
Fig. 3: The identical methyl marks of DNA and RNA methylation.

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Acknowledgements

This work is supported by the National Natural Science Foundation of PR China (no. 81570193 and no. 81770219, for QW).

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  1. These authors contributed equally: Lan Yao, Hua Yin, Mei Hong

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  1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Lan Yao, Hua Yin, Mei Hong, Yajun Wang, Tingting Yu, Yao Teng, Tingting Li & Qiuling Wu

  2. Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China

    Mei Hong

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Yao, L., Yin, H., Hong, M. et al. RNA methylation in hematological malignancies and its interactions with other epigenetic modifications. Leukemia 35, 1243–1257 (2021). https://doi.org/10.1038/s41375-021-01225-1

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