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p53, a translational regulator: contribution to its tumour-suppressor activity

Oncogene volume 34, pages 5513–5523 (2015)Cite this article

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Abstract

A growing body of evidences indicate that deregulation of translation contributes to tumourigenesis. In tumours, alterations of translational control of specific mRNAs encoding oncogenes or tumour suppressors have been extensively reported. Moreover, restricting the rate of protein synthesis has been shown to delays tumourigenesis in C-Myc overexpressing or PTEN deleted mice models. Finally, the specific inhibition of RNA polymerase I (RNA pol I) has been shown to kill cancer cells without affecting normal cells. It thus emerges that a tight coordination between the rate of global protein synthesis and a defined translational program is required to prevent tumour development. In this review, we expose the evidences supporting that p53 acts as a translational regulator. In addition, this review discusses the notion that the ability to maintain both a selective translational program and a low level of protein synthesis could directly contribute to the p53 tumour-suppressor activity.

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Acknowledgements

We apologize to those works that have not been cited in this article because of lack of space. This article was supported by CNRS, INSERM, Université Claude Bernard Lyon 1, Centre Léon Bérard, Fondation ARC pour la Recherche sur le Cancer (n° SFI20121205802), Ligue Nationale Contre le Cancer Comité Rhône-Alpes-Auvergne et Saône et Loire (n°13-763C), ANR (13-BSV8-0012-01 Ribometh) and PAIR Sein (n°ARC_INCa_LNCC_7625). VM was a recipient of a postdoctoral fellowship from Centre Léon Bérard. VM and J-JD are members of INSERM. FC is member of CNRS.

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  1. Cancer Cell Plasticity Department, Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France

    V Marcel, F Catez & J-J Diaz

  2. Université de Lyon, Université Lyon 1, ISPB, Lyon, France

    V Marcel, F Catez & J-J Diaz

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  1. V Marcel
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  2. F Catez
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Correspondence to V Marcel.

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Marcel, V., Catez, F. & Diaz, JJ. p53, a translational regulator: contribution to its tumour-suppressor activity. Oncogene 34, 5513–5523 (2015). https://doi.org/10.1038/onc.2015.25

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