The exosome, the major eukaryotic 3′ exoribonuclease acting in processing or degradation of a wide variety of RNA substrates, contains six subunits with predicted phosphorolytic activity and a single hydrolytic subunit. Recent data suggest that the phosphorolytic subunits of the yeast enzyme are catalytically inactive, and the hydrolytic subunit is solely responsible for the activity of the core exosome.
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References
Dziembowski, A., Lorentzen, E., Conti, E. & Seraphin, B. Nat. Struct. Mol. Biol., 13, 15–22 (2006).
Ishii, R., Nureki, O. & Yokoyama, S. J. Biol. Chem. 278, 32397–32404 (2003).
Harlow, L.S., Kadziola, A., Jensen, K.J. & Larsen, S. Prot. Science 13, 668–677 (2004).
Symmons, M.F., Jones, G.H. & Luisi, B.F. Structure 8, 1215–1226 (2000).
Symmons, M.F., Williams, M.G., Luisi, B.F., Jones, G.H. & Carpousis, A. Trends Biochem. Sci. 27, 11–18 (2002).
Lorentzen, E. et al. Nat. Struct. Mol. Biol. 12, 575–581 (2005).
Büttner, K., Wenig, K. & Hopfner, K.-P. Mol. Cell 20, 461–471 (2005).
Mitchell, P., Petfalski, E., Shevchenko, A., Mann, M. & Tollervey, D. Cell 91, 457–466 (1997).
Allmang, C. et al. Genes Dev. 13, 2148–2158 (1999).
Littauer, U.Z. & Soreq, H. in The Enzymes Vol. XV (ed. Boyer, P.D.) Part B, 518–553 (Acadamic Press, New York, 1982).
Lorentzen, E. & Conti, E. Mol. Cell 20, 473–481 (2005).
Chekanova, J.A., Shaw, R.J., Wills, M.A. & Belostotsky, D.A. J. Biol. Chem. 275, 33158–33166 (2000).
van Hoof, A. & Parker, R. Cell 99, 347–350 (1999).
Lorentzen, E. & Conti, E. Cell 125, 651–654 (2006).
Mohanty, B.K. & Kushner, S.R. Proc. Natl. Acad. Sci. USA 97, 11966–11971 (2000).
Kadaba, S. et al. Genes Dev. 18, 1227–1240 (2004).
LaCava, J. et al. Cell 121, 713–724 (2005).
Wyers, F. et al. Cell 121, 725–737 (2005).
Vanacova, S. et al. PLOS Biol. 3, e189 (2005).
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Wahle, E. Wrong PH for RNA degradation. Nat Struct Mol Biol 14, 5–7 (2007). https://doi.org/10.1038/nsmb0107-5
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DOI: https://doi.org/10.1038/nsmb0107-5
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