Acute pancreatitis is the most common and feared complication following endoscopic retrograde cholangiopancreatography (ERCP). Pharmacological prevention of post-ERCP pancreatitis has been disappointing, especially in high-risk patients. However, a prospective multicentre trial has demonstrated the efficacy of rectal administration of indomethacin for preventing post-ERCP pancreatitis in high-risk cases.
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Testoni, P. Can rectal NSAIDs prevent post-ERCP pancreatitis?. Nat Rev Gastroenterol Hepatol 9, 429–430 (2012). https://doi.org/10.1038/nrgastro.2012.117
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DOI: https://doi.org/10.1038/nrgastro.2012.117
