Systemic administration of anti-PCSK9 antibodies induces dramatic reductions in LDL-cholesterol levels, and the effect of this therapy on LDL-receptor activity seems to be additive to that of statin therapy. Inhibition of PCSK9 is potentially very important to the clinician, and should enable more patients to achieve their LDL-cholesterol-level goal.
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The author has received honoraria for lectures from and is a member of the advisory boards of Aegerion, Amgen, Astra Zeneca, Janssen, Kowa, MSD, Pfizer and Takeda.
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Betteridge, D. PCSK9—an exciting target for reducing LDL-cholesterol levels. Nat Rev Endocrinol 9, 76–78 (2013). https://doi.org/10.1038/nrendo.2012.254
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DOI: https://doi.org/10.1038/nrendo.2012.254
