Abstract
Asbestos has become the leading cause of occupationally related cancer death, and the second most fatal manufactured carcinogen (after tobacco). In the public's mind, asbestos has been a hazard since the 1960s and 1970s. However, the knowledge that the material was a mortal health hazard dates back at least a century, and its carcinogenic properties have been appreciated for more than 50 years.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Health & Safety Commission. Health & Safety Statistics 2000–01 (HSE Books, Norwich, 2001).
Wikeley, N. J. Asbestos and cancer: an early warning to the British TUC. Am. J. Indust. Med. 22, 449–454 (1992).
Wood, W. B. & Gloyne, S. R. Pulmonary asbestosis: a review of one hundred cases. Lancet 2, 1383–1385 (1934).
Lynch, K. M. & Smith, W. A. Pulmonary asbestosis. III. Carcinoma of the lung in asbestos-silicosis. Am. J. Cancer 24, 56–64 (1935).
Proctor, R. The Nazi War on Cancer 108–111 (Princeton Univ. Press, Princeton, New Jersey, 1999).
Ministry of Labour & Factory Inspectorate. Annual Report for 1947 79–80 (HMSO, London, 1949).
McLaughlin, A. I. G. The prevention of the dust diseases. Lancet 2, 49 (1953).
Schepers, G. W. H. Changing attitudes and opinions: asbestos and cancer 1934–1965. Am. J. Indust. Med. 22, 461–466 (1992).
Wyers, H. That Legislative Measures Have Proved Generally Effective in the Control of Asbestosis. Thesis, Glasgow Univ. (1946).
Tweedale, G. Magic Mineral to Killer Dust: Turner & Newall and the Asbestos Hazard 146 (Oxford Univ. Press, Oxford, 2000).
Castleman, B. I. Asbestos: Medical and Legal Aspects 4th edn 69 (Aspen Law & Business, Englewood Cliffs, New Jersey, 1996).
Lilienfeld, D. E. The silence: the asbestos industry and early occupational cancer research — a case study. Am. J. Public Health 81, 791–800 (1991).
Doll, R. Mortality from lung cancer in asbestos workers. Br. J. Indust. Med. 12, 81–86 (1955).
Greenberg, M. A study of lung cancer mortality in asbestos workers: Doll, 1955. Am. J. Indust. Med. 36, 31–47 (1999).
Ministry of Labour & Factory Inspectorate. Annual Report of HM Chief Inspector of Factories 39 MHSO, London, 1965).
Tweedale, G. Science or public relations?: the inside story of the Asbestosis Research Council. Am. J. Indust. Med. 38, 723–734 (2000).
Enterline, P. E. Changing attitudes and opinions regarding asbestos and cancer 1934–1965. Am. J. Indust. Med. 20, 685–700 (1991).
McCulloch, J. Asbestos Blues (James Currey Publishers, London, 2002).
Wagner, J. C., Sleggs, C. A. & Marchand, P. Diffuse pleural mesotheliomas and asbestos exposure in the North-Western Cape Province. Br. J. Indust. Med. 17, 260–271 (1960).
Selikoff, I. J. & Lee, D. H. K. Asbestos and Disease (Academic, New York, 1978).
Newhouse, M. L. & Thompson, H. Mesothelioma of pleura and peritoneum following exposure to asbestos in the London area. Br. J. Indust. Med. 22, 261–269 (1965).
Johnston, R. & McIvor, A. Lethal Work: A History of the Asbestos Tragedy in Scotland (Tuckwell, Glasgow, 2000).
Proctor, R. Cancer Wars (Basic Books, New York, 1995).
Smith, A. H. & Wright, C. C. Chrysotile asbestos is the main cause of pleural mesothelioma. Am. J. Indust. Med. 30, 252–266 (1996).
Stayner, L. T., Dankovic, D. & Lemen, R. A. Occupational exposure to chrysotile asbestos and cancer risk: a review of the amphibole hypothesis. Am. J. Public Health 86, 179–186 (1996).
Epstein, S. S. The Politics of Cancer Revisited (East Ridge Press, New York, 1998).
Doll, R. & Peto, J. Asbestos: Effects on Health of Exposure to Asbestos (HMSO, London, 1985).
Dalton, A. Asbestos Killer Dust (BSSRS Publications, London, 1979).
Tait, N. Asbestos Kills (privately published, London, 1976).
Peto, J., Hodgson, J. T., Matthews, F. E. & Jones, J. R. Continuing increase in mesothelioma mortality in Britain. Lancet 345, 535–539 (1995).
Peto, J., Decarli, A., La Vecchia, C., Levi, F. & Negri, E. The European mesothelioma epidemic. Br. J. Cancer 79, 666–672 (1999).
Health & Safety Commission. Health & Safety Statistics (HSE Books, Norwich, annual).
World Trade Organization. European Community — Measures Affecting Asbestos and Asbestos-Containing Products. Report of the Appellate Body, WT/DS135/AB/R, 12 March 2001.
Author information
Authors and Affiliations
Related links
Rights and permissions
About this article
Cite this article
Tweedale, G. Asbestos and its lethal legacy. Nat Rev Cancer 2, 311–314 (2002). https://doi.org/10.1038/nrc774
Issue Date:
DOI: https://doi.org/10.1038/nrc774
This article is cited by
-
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial
Nature Medicine (2021)
-
DNA methylation profiling of asbestos-treated MeT5A cell line reveals novel pathways implicated in asbestos response
Archives of Toxicology (2018)
-
Chrysotile and rock wool fibers induce chromosome aberrations and DNA damage in V79 lung fibroblast cells
Environmental Science and Pollution Research (2018)
-
Engineered nanomaterials: toward effective safety management in research laboratories
Journal of Nanobiotechnology (2016)
-
Standing the test of time: targeting thymidylate biosynthesis in cancer therapy
Nature Reviews Clinical Oncology (2014)