A recent paper in Science reports that for Schwann cells to initiate myelination, the Par-3 polarity protein must interact with the neurotrophin receptor p75NTR and relocate it to membrane domains of glia-axon contact.
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Taveggia, C., Salzer, J. PARsing the events of myelination. Nat Neurosci 10, 17–18 (2007). https://doi.org/10.1038/nn0107-17
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DOI: https://doi.org/10.1038/nn0107-17