Antisense oligonucleotides can have dramatic effects, but a recent paper suggests that the mechanism isn't always based on nucleotide sequence interactions.
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Holt, J. A ‘senseless’ immune response to DNA. Nat Med 1, 407–408 (1995). https://doi.org/10.1038/nm0595-407
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DOI: https://doi.org/10.1038/nm0595-407