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A serious target for laughing gas

The widely used inhalational general anesthetic nitrous oxide inhibits the NMDA class of glutamate-activated receptor channels at clinically relevant concentrations (pages 460–463).

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References

  1. Paris, J.A. The Life of Sir Humphry Davy (Colburn and Bentley, London, 1831).

    Google Scholar 

  2. Davy, H. Some experiments on the gaseous oxide of azote. Nicholson journal 3, 55–56 (1800).

    Google Scholar 

  3. Jevtovic-Todorovic, V. et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature Med. 4, 460–463 (1998).

    Article  CAS  Google Scholar 

  4. Franks, N.P. & Lieb, W.R. Molecular and cellular mechanisms of general anaesthesia. Nature 367, 607–614 (1994).

    Article  CAS  Google Scholar 

  5. Franks, N.P. & Lieb, W.R. An anesthetic-sensitive superfamily of neurotransmittergated ion channels. J. Clin. Anesth. 8, S3–S7 (1996).

    Article  Google Scholar 

  6. Brockmeyer, D.M. & Kendig, I.J. Selective effects of ketamine on amino acid-mediated pathways in neonatal rat spinal cord. Br. J. Anaesth. 74, 79–84 (1995).

    Article  CAS  Google Scholar 

  7. Rang, H.P., Dale, M.M. & Ritter, J.M., Pharmacology (Churchill Livingstone, New York, 1995).

    Google Scholar 

  8. Small, D.L. & Buchan, A.M. NMDA antagonists: their role in neuroprotection. Int. Rev. Neurobiol. 40, 137–171 (1997).

    Article  CAS  Google Scholar 

  9. Olney, I.W., Labruyere, J. & Price, M.T. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244, 1360–1362 (1989).

    Article  CAS  Google Scholar 

  10. Olney, J.W. et al. NMDA antagonist neurotoxicity: mechanism and prevention. Science 254, 1515–1518 (1991).

    Article  CAS  Google Scholar 

Download references

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Franks, N., Lieb, W. A serious target for laughing gas. Nat Med 4, 383–384 (1998). https://doi.org/10.1038/nm0498-383

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