Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to the Editor
  • Published:

Elevated plasma levels of TGF-β1 in patients with invasive prostate cancer

Nature Medicine volume 1, pages 282–284 (1995)Cite this article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rinker-Schaeffer, C.W., Partin, A.W., Isaacs, W.B., Coffey, D.S. & Isaacs, J.T. Molecular and cellular changes associated with the acquisition of metastatic ability by prostatic cancer cells. Prostate 25, 249–265 (1994).

    Article  CAS  Google Scholar 

  2. Dalai, B.I., Keown, P.A. & Greenberg, A.H. Im-munocytochemical localization of secreted transforming growth factor-β1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am. J. Pathol. 143, 381–389 (1993).

    Google Scholar 

  3. Truong, L.D. et al. Association of transforming growth factor-β1 with prostate cancer: An im-munohistochemical study. Hum. Pathol. 24, 4–9 (1993).

    Article  CAS  Google Scholar 

  4. Smith, J.A. Jr & Scaletsky, R. Future directions in tumor marker technology for prostate cancer. Urol. Clin. North Am. 20, 771–777 (1993).

    PubMed  Google Scholar 

  5. Thompson, T.C. Growth factors and oncogenes in prostate cancer. Cancer Cells 2, 345–354 (1990).

    CAS  Google Scholar 

  6. Merz, V.W. et al. Elevated transforming growth factor-β1 and b3 mRNA levels are associated with ras+ and myc− induced carcinomas in reconstituted mouse prostate: Evidence for a paracrine role during progression. Molec. Endocrinol. 5, 503–513 (1991).

    Article  CAS  Google Scholar 

  7. Steiner, M.S. & Barrack, E.R. Transforming growth factor-β1 overproduction in prostate cancer: Effects on growth in vivo and in vitro . Molec. Endocrinol. 6, 15–25 (1992).

    CAS  Google Scholar 

  8. Ikeda, T., Lioubin, M.N. & Marquardt, H. Human transforming growth factor type b2: Production by a prostatic adenocarcinoma cell line, purification and initial characterization. Biochemistry 26, 2406–2410 (1987).

    Article  CAS  Google Scholar 

  9. Shirai, Y. et al. Elevated levels of plasma transforming growth factor-β1 in patients with hepatocellular carcinoma. Jap. J. Cancer Res. 83, 676–679 (1992).

    Article  CAS  Google Scholar 

  10. Carter, H.B., Piantadosi, S. & Isaacs, J.I. Clinical evidence for and implications of the multistep development of prostate cancer. J. Urol. 143, 742–746 (1990).

    Article  CAS  Google Scholar 

  11. Nishiya, M., Miller, G.J., Lookner, D.H. & Craw-ford, E.D. Prostate specific antigen density in patients with histologically proven prostate carcinoma. Cancer 74, 3002–3009 (1994).

    Article  CAS  Google Scholar 

  12. Thompson, T.C. et al. Transforming growth factor β1 as a biomarker for prostate cancer. J. cell. Biochem. 16, H, 54–61 (1992).

    Article  Google Scholar 

  13. Goldstein, D., O'Leary, M. & Mitchen, J. Effects of interferon beta and transforming growth factor beta on prostatic cell lines. J. Urol. 146, 1173–1177, (1991).

    Article  CAS  Google Scholar 

  14. Welch, D.R., Fabra, A. & Nakajima, M. Transforming growth factor β1 stimulates mammary adenocarcinoma cell invasion and metastatic potential. Proc. natn. Acad. Sci. U.S.A. 87, 7678–7682 (1990).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, 10461, USA

    Vesna Ivanovic, Arnold Melman, Brian Davis-Joseph, Mira Valcic & Jan Geliebter

Authors
  1. Vesna Ivanovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arnold Melman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Brian Davis-Joseph
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mira Valcic
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jan Geliebter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ivanovic, V., Melman, A., Davis-Joseph, B. et al. Elevated plasma levels of TGF-β1 in patients with invasive prostate cancer. Nat Med 1, 282–284 (1995). https://doi.org/10.1038/nm0495-282

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0495-282

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing