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New dimensions of CIITA

Nature Immunology volume 9, pages 713–714 (2008)Cite this article

CIITA encodes the 'master regulator' of the expression of major histocompatibility complex class II genes. A new layer of complexity has been identified in the control of CIITA expression, which involves the formation of a complex three-dimensional chromatin structure promoted by interactions among many distant regulatory elements.

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Figure 1: The CIITA locus and its four promoters, pI, pII, pIII and pIV.

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Authors and Affiliations

  1. Walter Reith is in the Department of Pathology and Immunology, University of Geneva Medical School, CH-1211 Geneva, Switzerland. walter.reith@medecine.unige.ch,

    Walter Reith

  2. Jeremy M. Boss is in the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.,

    Jeremy M Boss

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  1. Walter Reith
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Reith, W., Boss, J. New dimensions of CIITA. Nat Immunol 9, 713–714 (2008). https://doi.org/10.1038/ni0708-713

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