The transcription factor(s) controlling TReg cell development are not definitely known. The finding that these cells specifically express Foxp3 provides a better understanding of their development and function at the molecular level.
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Acknowledgements
We thank B. Stockinger, R. Marques, P.L. Vieira, D. Robinson, J.P. Pereira and A. Bandeira for helpful comments.
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O'Garra, A., Vieira, P. Twenty-first century Foxp3. Nat Immunol 4, 304–306 (2003). https://doi.org/10.1038/ni0403-304
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DOI: https://doi.org/10.1038/ni0403-304
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