The transcription factor Foxp1 helps maintain the quiescence of naive T cells by inhibiting IL-7Rα expression and diminishing signaling by the kinase Erk.
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Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice
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Skon, C., Jameson, S. Fox factors fight over T cell quiescence. Nat Immunol 12, 522–524 (2011). https://doi.org/10.1038/ni.2040
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DOI: https://doi.org/10.1038/ni.2040
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Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice
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