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Genetic mosaicism in normal tissues of Wilms' tumour patients

Nature Genetics volume 3, pages 127–131 (1993)Cite this article

Abstract

We describe the partial loss of heterozygosity (LOH) at chromosome 11 p loci in normal tissues (normal kidney and/or blood) from four of 67 Wilms' tumour patients. Autologous tumour DNA showed complete loss of the same, maternally derived, alleles. These observations indicate that the normal tissues were mosaic for cells heterozygous and homozygous for 11 p markers and that tumours subsequently developed from the homozygous cells that had undergone an 11 p somatic recombination event. We suggest that LOH for 11 p alleles is compatible with normal growth and differentiation and is significant pathologically only when accompanied by other genetic alterations.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    Lian-Yu Chao, Vicki Huff & Grady F. Saunders

  2. Department of Pediatrics and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, 75235, USA

    Gail Tomlinson

  3. NF Institute, 5415 Briggs Avenue, La Crescenta, California, 91214, USA

    Vincent M. Riccardi

  4. Department of Experimental Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    Louise C. Strong

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  1. Lian-Yu Chao
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  6. Grady F. Saunders
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Chao, LY., Huff, V., Tomlinson, G. et al. Genetic mosaicism in normal tissues of Wilms' tumour patients. Nat Genet 3, 127–131 (1993). https://doi.org/10.1038/ng0293-127

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