The discovery of new risk variants for systemic lupus erythematosis (SLE), particularly around lymphocyte signaling pathways and integrins involved in clearing complement, provides fresh insights into this common human autoimmune disease. Understanding the role of the variants in disease pathophysiology and translating these findings into new therapies present major and urgent challenges to medical scientists.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Nath, S. K. et al. Nat. Genet. 40, 152–154 (2008).
The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN) et al. Nat. Genet. 40, 204–210 (2008).
Kozyrev, S.V. et al. Nat. Genet. 40, 211–216 (2008).
Hom, G. et al. N. Engl. J. Med., (in the press).
Rhodes, B. & Vyse, T.J. Autoimmunity 40, 550–559 (2007).
Hepburn, A.L. et al. Clin. Exp. Immunol. 146, 133–145 (2006).
Vang, T., Miletic, A.V., Bottini, N. & Mustelin, T. Autoimmunity 40, 453–461 (2007).
Remmers, E.F. et al. N. Engl. J. Med. 357, 977–986 (2007).
Lowe, C.E. et al. Nat. Genet. 39, 1074–1082 (2007).
Todd, J.A. et al. Nat. Genet. 39, 857–864 (2007).
The International Multiple Sclerosis Genetics Consortium. N. Engl. J. Med. 357, 851–862 (2007).
Brand, O.J. et al. Clin. Endocrinol. 66, 508–512 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Maier, L., Hafler, D. The developing mosaic of autoimmune disease risk. Nat Genet 40, 131–132 (2008). https://doi.org/10.1038/ng0208-131
Issue Date:
DOI: https://doi.org/10.1038/ng0208-131
This article is cited by
-
Macrophages from lupus-prone MRL mice have a conditional signaling abnormality that leads to dysregulated expression of numerous genes
Immunogenetics (2011)
-
Multiple sclerosis genetics—is the glass half full, or half empty?
Nature Reviews Neurology (2010)
-
Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis
Genes & Immunity (2009)
-
The expanding genetic overlap between multiple sclerosis and type I diabetes
Genes & Immunity (2009)
-
The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
Nature Reviews Genetics (2008)