Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Induction of Epstein-Barr Virus-related Membrane Antigens by 5-Iododeoxyuridine in Non-producer Human Lymphoblastoid Cells

Nature New Biology volume 246, pages 70–72 (1973)Cite this article

Abstract

REPORTS have recently appeared concerning the activation by halogenated pyrimidines of a repressed Epstein-Barr virus (EBV) genome1–7. We have demonstrated the induction of two EBV-related early and late antigenic products, which represent early antigens (EA)8, 9 and viral capsid antigens (VCA)10, respectively, in non-producer human lymphoblastoid NC-37 and Raji cells by 5-bromodeoxyuridine (BUdR) and 5-iododeoxyuridine (IUdR). These findings have prompted us to investigate further whether membrane antigens (MA)11, another major product related to EBV, can be induced by halogenated pyrimidines as well. We describe here that a marked MA induction occurred rapidly in all individual clones of non-producer NC-37 and Raji cells by exposure to IUdR (ref. 12).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hampar, B., Derge, J. G., Martos, L. M., and Walker, J. L., Proc. natn. Acad. Sci. U.S.A., 69, 78 (1972).

    Article  CAS  Google Scholar 

  2. Gerber, P., Proc. natn. Acad. Sci. U.S.A., 69, 83 (1972).

    Article  CAS  Google Scholar 

  3. Sugawara, K., Mizuno, F., and Osato, T., Nature new Biol., 239, 242 (1972).

    Article  CAS  Google Scholar 

  4. Glaser, R., and Rapp, F., J. Virol., 10, 288 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Gerber, P., and Lucas, S., Proc. Soc. exp. Biol. Med., 141, 431 (1972).

    Article  CAS  Google Scholar 

  6. Klein, G., and Dombos, L., Int. J. Cancer, 11, 327 (1973).

    Article  CAS  Google Scholar 

  7. Sugawara, K., and Osato, T., Nature new Biol., 243, 209 (1973).

    Article  CAS  Google Scholar 

  8. Henle, W., Henle, G., Zajac, B. A., Pearson, G., Waubke, R., and Scriba, M., Science, NY., 169, 188 (1970).

    Article  CAS  Google Scholar 

  9. Henle, G., Henle, W., and Klein, G., Int. J. Cancer, 8, 272 (1971).

    Article  CAS  Google Scholar 

  10. Henle, G., and Henle, W., J. Bact., 91, 1248 (1966).

    CAS  PubMed  Google Scholar 

  11. Klein, G., Clifford, P., Klein, E., and Stjernswärd, J., Proc. natn. Acad. Sci. U.S.A., 55, 1628 (1966).

    Article  CAS  Google Scholar 

  12. Sugawara, K., Mizuno, F., and Osato, T., Proc. Am. Ass. Cancer Res., 64, 36 (1973).

    Google Scholar 

  13. Durr, F. E., Monroe, J. H., Schmitter, R., Traul, K. A., and Hirshaut, Y., Int. J. Cancer, 6, 436 (1970).

    Article  CAS  Google Scholar 

  14. Epstein, M. A., Achong, B. G., Barr, Y. M., Zajac, B., Henle, G., and Henle, W., J. natn. Cancer Inst., 37, 547 (1966).

    CAS  Google Scholar 

  15. Hinuma, Y., Konn, M., Yamaguchi, J., Wudarski, D. J., Blakeslee, J. R., jun., and Grace, J. T., jun., J. Virol., 1, 1045 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Hinuma, Y., and Grace, J. T., jun., Cancer, 22, 1089 (1968).

    Article  CAS  Google Scholar 

  17. Sugawara, K., Mizuno, F., and Osato, T., Nature new Biol., 233, 106 (1971).

    Article  CAS  Google Scholar 

  18. Osato, T., Sugawara, K., and Mizuno, F., in Oncogenesis and Herpesviruses (edit, by Biggs, P. M., de-Thé, G., and Payne, L. N.), 308 (International Agency for Research against Cancer, Lyon, 1972).

    Google Scholar 

  19. Klein, G., in Oncogenesis and Herpesviruses (edit, by Biggs, P. M., de-Thé, G., and Payne, L. N.), 295 (International Agency for Research against Cancer, Lyon,(1972).

    Google Scholar 

  20. Glaser, R., and Nonoyama, M., Proc. Am. Ass. Cancer Res., 64, 73 (1973).

    Google Scholar 

  21. Sugawara, K., and Osato, T., Proc. Jap. Ass. Cancer Res., 32, 6 (1973).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Virology, Cancer Institute, Hokkaido University, School of Medicine, Sapporo, N15 W7

    KENJI SUGAWARA, FUMIO MIZUNO & TOYORO OSATO

Authors
  1. KENJI SUGAWARA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. FUMIO MIZUNO
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. TOYORO OSATO
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SUGAWARA, K., MIZUNO, F. & OSATO, T. Induction of Epstein-Barr Virus-related Membrane Antigens by 5-Iododeoxyuridine in Non-producer Human Lymphoblastoid Cells. Nature New Biology 246, 70–72 (1973). https://doi.org/10.1038/newbio246070a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio246070a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing