Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Further Evidence for Posttranscriptional Control of Inducible Tyrosine Aminotransferase Synthesis in Cultured Hepatoma Cells

Abstract

The posttranscriptional control model for inducible enzymes is supported by evidence that the action of the RNA synthesis inhibitor, actinomycin D, in inhibiting the deinduction of inducible tyrosine aminotransferase is not due to its inhibition of enzyme degradation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Tomkins, G. M., & Martin, jun., D. W., Ann. Rev. Genetics, 4, 91 (1970).

    Article  CAS  Google Scholar 

  2. Levinson, B. B., Baxter, J. D., Rousseau, G. G., & Tomkins, G. M., Science, 175, 189 (1972).

    Article  CAS  PubMed  Google Scholar 

  3. Jensen, E. V., Numata, M., Brecher, P. I., & DeSombre, E. R., in The Biochemistry of Steroid Hormone Action, Biochemistry Soc. Symp., No. 32 (edit. by Smellie, R. M. S.), 133 (Academic Press, New York, 1971).

    Google Scholar 

  4. Baxter, J. D., & Tomkins, G. M., Proc. US Nat. Acad. Sci., 68, 932 (1971).

    Article  CAS  Google Scholar 

  5. Baxter, J. D., & Tomkins, G. M., Proc. US Nat. Acad. Sci., 65, 709 (1970).

    Article  CAS  Google Scholar 

  6. Rousseau, G. G., Baxter, J. D., & Tomkins, G. M., Proc. US Nat. Acad. Sci. (in the press).

  7. King, R. J. B., Beard, V., Gordon, J., Pooley, A. S., Smith, J. A., Steggles, A. W., & Vertes, M., in Ad. Biosciences (edit. by Raspe, G.), 7, 21 (Pergamon, Vieweg, Braunschweig, 1971).

    Google Scholar 

  8. Mainwaring, W. I. P., & Mangan, F. R., in Adv. Biosciences (edit. by Raspe, G.), 7, 165 (Pergamon, Vieweg, Braunschweig, 1971).

    Google Scholar 

  9. Peterkofsky, B., & Tomkins, G. M., J. Mol. Biol., 30, 49 (1967).

    Article  CAS  PubMed  Google Scholar 

  10. Peterkofsky, B., & Tomkins, G. M., Proc. US Nat. Acad. Sci., 60, 222 (1968).

    Article  CAS  Google Scholar 

  11. Granner, D. K., Hayashi, S., Thompson, E. B., & Tomkins, G. M., J. Mol. Biol., 35, 291 (1968).

    Article  CAS  PubMed  Google Scholar 

  12. Granner, D. K., Thompson, E. B., & Tomkins, G. M., J. Biol. Chem., 245, 1472 (1970).

    CAS  PubMed  Google Scholar 

  13. Baxter, J. D., Rousseau, G. G., & Tomkins, G. M., Fed. Proc., 30, 1048, Abstr. (1971).

    Google Scholar 

  14. Garren, L. D., Howell, R. R., Tomkins, G. M., & Crocco, R. M., Proc. US Nat. Acad. Sci., 52, 1121 (1964).

    Article  CAS  Google Scholar 

  15. Thompson, E. B., Granner, D. K., & Tomkins, G. M., J. Mol. Biol., 54, 159 (1970).

    Article  CAS  PubMed  Google Scholar 

  16. Thompson, E. B., Tomkins, G. M., & Curran, J. F., Proc. US Nat. Acad. Sci., 56, 296 (1966).

    Article  CAS  Google Scholar 

  17. Tomkins, G. M., Martin, jun., D. W., Stellwagen, R. H., Baxter, J. D., Mamont, P., & Levinson, B. B., Cold Spring Harbor Symp. Quant. Biol., 35, 635 (1970).

    Article  CAS  Google Scholar 

  18. Tomkins, G. M., Gelehrter, T. D., Granner, D. K., Martin, jun., D. W., Samuels, H. H., & Thompson, E. B., Science, 166, 1474 (1969).

    Article  CAS  PubMed  Google Scholar 

  19. Martin, jun., D. W., Tomkins, G. M., & Granner, D. K., Proc. US Nat. Acad. Sci., 62, 248 (1969).

    Article  CAS  Google Scholar 

  20. Martin, jun., D. W., Tomkins, G. M., & Bresler, M., Proc. US Nat. Acad. Sci., 63, 842 (1969).

    Article  CAS  Google Scholar 

  21. Martin, jun., D. W., & Tomkins, G. M., Proc. US Nat. Acad. Sci., 65, 1064 (1970).

    Article  CAS  Google Scholar 

  22. Reel, J. R., Lee, K. L., & Kenney, F. T., J. Biol. Chem., 245, 5800 (1970).

    CAS  PubMed  Google Scholar 

  23. Hershko, A., & Tomkins, G. M., J. Biol. Chem., 246, 710 (1971).

    CAS  PubMed  Google Scholar 

  24. Diamondstone, T. I., Anal. Biochem., 16, 395 (1966).

    Article  CAS  Google Scholar 

  25. Valeriote, F. A., Auricchio, F., Tomkins, G. M., & Riley, D., J. Biol. Chem., 244, 3618 (1969).

    CAS  PubMed  Google Scholar 

  26. Auricchio, F., Martin, jun., D. W., & Tomkins, G. M., Nature, 224, 806 (1969).

    Article  CAS  PubMed  Google Scholar 

  27. Hershko, A., Mamont, P., Shields, R., & Tomkins, G. M., Nature New Biology, 232, 206 (1971).

    Article  CAS  PubMed  Google Scholar 

  28. Goodwin, B. C., & Sizer, I. W., Science, 148, 242 (1965).

    Article  CAS  PubMed  Google Scholar 

  29. Vogel, R. H., & Vogel, H. J., Biochem. Biophys. Res. Commun., 18, 768 (1965).

    Article  CAS  Google Scholar 

  30. Rosen, F., Raina, P. N., Milholland, R. J., & Nichol, C. A., Science, 146, 661 (1964).

    Article  CAS  PubMed  Google Scholar 

  31. Nitowsky, H., Geller, S., & Casper, R., Fed. Proc., 23, 556 (1964).

    Google Scholar 

  32. Moog, F., Science, 144, 414 (1964).

    Article  CAS  PubMed  Google Scholar 

  33. McCoy, E. E., & Ebadi, M., Biochem. Biophys. Res. Commun., 26, 265 (1967).

    Article  CAS  PubMed  Google Scholar 

  34. Ernster, L., & Orrenius, S., Fed. Proc., 24, 1190 (1965).

    CAS  PubMed  Google Scholar 

  35. Wust, C. J., & Hanna, M. G., J. Reticuloendothelial Soc., 3, 415 (1966).

    CAS  Google Scholar 

  36. Speirs, R. S., Life Sciences, 4, 343 (1965).

    Article  CAS  PubMed  Google Scholar 

  37. Geller, B. D., & Speirs, R. S., Proc. Soc Exp. Biol. Med., 117, 782 (1964).

    Article  CAS  PubMed  Google Scholar 

  38. Taliaferro, W. H., & Taliaferro, L. G., Proc. US Nat. Acad. Sci., 66, 1036 (1970).

    Article  CAS  Google Scholar 

  39. Ambrose, C. T., J. Exp. Med., 130, 1003 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Stavitsky, A. B., & Gusdon, jun., J. P., Bact. Revs., 30, 418 (1966).

    CAS  Google Scholar 

  41. Smiley, J. D., Heard, J. G., & Ziff, M., J. Exp. Med., 119, 881 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Noguchi, T., J. Faculty of Science, Univ. Tokyo, Sect. IV, Zool., 11, 255 (1967).

    CAS  Google Scholar 

  43. Nebert, D. W., & Bausserman, L. L., Mol. Pharmacol., 6, 304 (1970).

    CAS  PubMed  Google Scholar 

  44. O'Malley, B., Biochemistry, 6, 2546 (1967).

    Article  CAS  PubMed  Google Scholar 

  45. DeMatteis, F., Biochem. J., 109, 775 (1968).

    Article  CAS  Google Scholar 

  46. Millar, J. A., Cumming, R. L. C., Smith, J. A., & Goldberg, A., Biochem. J., 119, 643 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Rivlin, R. S., & Langdon, R. G., Adv. Enzyme Regulation, 4, 45 (1966).

    Article  CAS  Google Scholar 

  48. Sols, A., Sillero, A., & Salas, J., J. Cell Comp. Physiol., 66, 23 (1965).

    Article  CAS  Google Scholar 

  49. Hilf, R., Michel, I., Silverstein, G., & Bell, C., Cancer Res., 25, 1854 (1965).

    CAS  PubMed  Google Scholar 

  50. Alescio, T., Moscona, M., & Moscona, A. A., Exp. Cell Res., 61, 342 (1970).

    Article  CAS  PubMed  Google Scholar 

  51. Moscona, A. A., Moscona, M., & Jones, R. E., Biochem. Biophys. Res. Commun., 39, 943 (1970).

    Article  CAS  PubMed  Google Scholar 

  52. Moscona, A. A., Moscona, M. H., & Saenz, N., Proc. US Nat. Acad. Sci., 61, 160 (1968).

    Article  CAS  Google Scholar 

  53. Weissman, H., & Ben-Or, S., Biochem. Biophys. Res. Commun., 41, 260 (1970).

    Article  CAS  PubMed  Google Scholar 

  54. Stubbs, D. W., & Haufrect, D. B., Arch. Biochem. Biophys., 124, 365 (1968).

    Article  CAS  PubMed  Google Scholar 

  55. McCarl, R. L., & Shaler, R. C., J. Cell Biol., 40, 850 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Tan, Y. H., Armstrong, J. A., Ke, Y. H., & Ho, M., Proc. US Nat. Acad. Sci., 67, 464 (1970).

    Article  CAS  Google Scholar 

  57. Chany, C., Fournier, F., & Rousset, S., Nature, 230, 113 (1971).

    Article  CAS  Google Scholar 

  58. Vilcek, J., & Ng, M. H., J. Virol., 7, 588 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Mathan, D. S., Genetics, 57, 15 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  60. Eagle, G. R., & Robinson, D. S., Biochem. J., 93, 10 c (1964).

    Article  CAS  Google Scholar 

  61. Whittaker, J. R., J. Exp. Zool., 169, 143 (1968).

    Article  CAS  PubMed  Google Scholar 

  62. Korner, A., & Hogan, B. L. M., Proc. Second Intern. Symp. Growth Hormone, Milan, 1971 (edit. by Pecile, A. P. (Excepta Medica Foundation, in the press).

  63. Schimke, R. T., Excerpta Medical International Congress Series, 204, 60 (1969).

    Google Scholar 

  64. Fischer, C. R., Genetics, 57, 189 (1967).

    Google Scholar 

  65. Pollock, M. R., Biochim. Biophys. Acta, 76, 80 (1963).

    Article  CAS  PubMed  Google Scholar 

  66. Both, G. W., McInnes, J. L., May, B. K., & Elliott, W. H., Biochem. Biophys. Res. Commun., 42, 750 (1971).

    Article  CAS  PubMed  Google Scholar 

  67. IhIe, J. N., & Dure, L., Biochem. Biophys. Res. Commun., 38, 995 (1970).

    Article  Google Scholar 

  68. Papaconstantinou, J., Stewart, J. A., & Koehn, P. V., Biochim. Biophys. Acta, 114, 428 (1966).

    Article  CAS  PubMed  Google Scholar 

  69. Christopher, C. W., Ishikawa, K., & Amos, H., Cell Tissue Kinet., 4, 75 (1971).

    CAS  PubMed  Google Scholar 

  70. Morris, G. E., & Korner, A., FEBS Lett., 10, 165 (1970).

    Article  CAS  PubMed  Google Scholar 

  71. Morris, G. E., & Korner, A., Biochim. Biophys. Acta, 208, 404 (1970).

    Article  CAS  PubMed  Google Scholar 

  72. Mayol, R. F., & Thayer, S. A., Biochemistry, 9, 2484 (1970).

    Article  CAS  PubMed  Google Scholar 

  73. Coleman, G., & Elliott, W. H., Nature, 202, 1083 (1964).

    Article  CAS  PubMed  Google Scholar 

  74. Coleman, G., & Elliott, W. H., Biochem. J., 95, 699 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. McAuslan, B. R., Virology, 21, 383 (1963).

    Article  CAS  PubMed  Google Scholar 

  76. Horowitz, N. H., Feldman, H. M., & Pall, M. L., J. Biol. Chem., 245, 2784 (1970).

    CAS  PubMed  Google Scholar 

  77. Schneider, J. A., & Weiss, M. C., Proc. US Nat. Acad. Sci., 68, 127 (1971).

    Article  CAS  Google Scholar 

  78. Delia Corte, E., & Stirpe, F., Biochem. J., 102, 520 (1967).

    Article  Google Scholar 

  79. Brown, I. N., Nature, 204, 487 (1964).

    Article  CAS  PubMed  Google Scholar 

  80. Scarano, E., de Petrocellis, B., & Augusti-Tocco, G., Biochim. Biophys. Acta, 87, 174 (1964).

    CAS  PubMed  Google Scholar 

  81. Horowitz, N. H., Fling, M., Feldman, H. M., Pall, M. L., & Froehner, S. C., Developmental Biol., 21, 147 (1970).

    Article  CAS  Google Scholar 

  82. Barnett, W. E., Brockman, H. E., Biochem. Biophys. Res. Commun., 7, 199 (1962).

    Article  CAS  PubMed  Google Scholar 

  83. Levitan, I. B., & Webb, T. E., Biochim. Biophys. Acta, 155, 632 (1968).

    Article  CAS  PubMed  Google Scholar 

  84. Pinsky, L., & Krooth, R. S., Proc. US Nat. Acad. Sci., 57, 1267 (1967).

    Article  CAS  Google Scholar 

  85. Pinsky, L., & Krooth, R. S., Proc. US Nat. Acad. Sci., 57, 925 (1967).

    Article  CAS  Google Scholar 

  86. Moscona, A. A., Moscona, M., & Jones, R. E., Biochem. Biophys. Res. Commun., 39, 943 (1970).

    Article  CAS  PubMed  Google Scholar 

  87. Merritt, K., & Johnson, A. G., J. Immunol., 91, 266 (1963).

    CAS  PubMed  Google Scholar 

  88. Rosen, B., J. Mol. Biol., 11, 845 (1965).

    Article  CAS  PubMed  Google Scholar 

  89. Sundaram, T. K., Biochim. Biophys. Acta, 138, 611 (1967).

    Article  CAS  PubMed  Google Scholar 

  90. Benzer, S., & Champe, S. P., Proc. US Nat. Acad. Sci., 47, 1025 (1961).

    Article  CAS  Google Scholar 

  91. Levinson, B. B., Tomkins, G. M., & Stellwagen, R. H., J. Biol. Chem., 246, 6297 (1971).

    CAS  PubMed  Google Scholar 

  92. Weyter, F. W., Carnevale, H. M., & Jones, E. E., Biochem. Biophys. Res. Commun., 43, 862 (1971).

    Article  CAS  PubMed  Google Scholar 

  93. Buskirk, H. H., Crim, J. A., & Petering, H. G., Fed. Proc., 22, 500 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

TOMKINS, G., LEVINSON, B., BAXTER, J. et al. Further Evidence for Posttranscriptional Control of Inducible Tyrosine Aminotransferase Synthesis in Cultured Hepatoma Cells. Nature New Biology 239, 9–14 (1972). https://doi.org/10.1038/newbio239009a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio239009a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing