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Induction of Acetylcholine Esterase Activity in a Mouse Neuroblastoma

Nature New Biology volume 233, pages 79–80 (1971)Cite this article

Abstract

TISSUE culture lines of mouse neuroblastoma C1300 contain acetylcholine esterase1, the specific activity of which depends on the conditions of growth, for the inhibition of cell division leads to an increase in esterase activity2,3. Although this suggests that the cessation of division is directly responsible for increased enzyme synthesis, it may also be that the increase of specific activity is the result of (1) neurite formation by differentiating neuroblast cells or (2) events accompanying ageing and cell death. This article describes experiments designed to distinguish between these hypotheses and to examine the regulation of esterases in other tissue culture lines.

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Authors and Affiliations

  1. The Salk Institute, PO Box 1809, San Diego, California, 92112

    DAVID SCHUBERT, HELGI TARIKAS, A. JOHN HARRIS & STEPHEN HEINEMANN

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  1. DAVID SCHUBERT
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  2. HELGI TARIKAS
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  3. A. JOHN HARRIS
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  4. STEPHEN HEINEMANN
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SCHUBERT, D., TARIKAS, H., HARRIS, A. et al. Induction of Acetylcholine Esterase Activity in a Mouse Neuroblastoma. Nature New Biology 233, 79–80 (1971). https://doi.org/10.1038/newbio233079a0

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