Crk-like (CrkL) is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. Structural investigations show that the intramolecular assembly of CrkL is entirely distinct from that of CrkII, shedding light on how CrkL specifically mediates Bcr-Abl signaling.
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Kobashigawa, Y., Inagaki, F. CrkL is not Crk-like. Nat Chem Biol 8, 504–505 (2012). https://doi.org/10.1038/nchembio.963
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DOI: https://doi.org/10.1038/nchembio.963
