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Neuroinflammation

Modulating mighty microglia

The small molecule inflachromene was discovered as a microglia-selective inhibitor of the central nervous system proinflammatory response and found to target HMGB2 and HMGB1 to impair proinflammatory signaling in microglia, resulting in neuroprotection.

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Figure 1: ICM protects neurons and myelin through inhibition of microglial HMGB1 and HMGB2.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Michelle L Block.

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Block, M. Modulating mighty microglia. Nat Chem Biol 10, 988–989 (2014). https://doi.org/10.1038/nchembio.1691

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