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Fat or bone? A non-canonical decision

Nature Cell Biology volume 9, pages 1229–1231 (2007)Cite this article

The transcription factor PPAR-γ determines whether mesenchymal stem cells differentiate into adipocytes or osteoblasts. The finding that non-canonical Wnt signalling represses PPAR-γ through assembly of a nuclear corepressor complex containing the histone methyltransferase SETDB1 provides the first insight into how extracellular signals can regulate chromatin modification.

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Figure 1: Model for differentiation of adipocytes and osteoblasts from a common bone marrow mesenchymal precursor.

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Authors and Affiliations

  1. Thomas Günther and Roland Schüle are at the Universitäts-Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany. roland.schuele@uniklinik-freiburg.de,

    Thomas Günther & Roland Schüle

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  1. Thomas Günther
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  2. Roland Schüle
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Günther, T., Schüle, R. Fat or bone? A non-canonical decision. Nat Cell Biol 9, 1229–1231 (2007). https://doi.org/10.1038/ncb1107-1229

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