The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabilizing N-terminal residues. This pathway is known to control the import of peptides, chromosome stability and cardiovascular development. A new report identifies yet another function of the N-end rule pathway: the regulation of apoptosis through degradation of Drosophila melanogaster DIAP1.
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References
Metzstein, M.M., Stanfield, G.M. & Horvitz, H.R. Trends Genet. 14, 410–416 (1998).
Guo, M. & Hay, B.A. Curr. Opin. Cell Biol. 11, 745–752 (1999).
Salvesen, G.S. & Duckett, C.S. Nature Rev. Mol. Cell Biol. 3, 401–410 (2002).
Yoo, S.J.Y. et al. Nature Cell Biol. 4, 416–424 (2002).
Yang, Y., Fang, S., Jensen, J.P., Weissman, A.M. & Ashwell, J.D. Science 288, 874–877 (2000).
Ryoo, H.D., Bergmann, A., Gonen, H., Ciechanover, A. & Steller, H. Nature Cell Biol. 4, 432–438 (2002).
Olson, M.R. et al. J. Biol. Chem. 278, 4028–4034 (2003).
Ditzel, M. et al. Nature Cell Biol. 5, 467–473 (2003).
Bachmair, A., Finley, D. & Varshavsky, A. Science 234, 179–186 (1986).
Varshavsky, A. Proc. Natl Acad. Sci. USA 93, 12142–12149 (1996).
Turner, G.C., Du, F. & Varshavsky, A. Nature 405, 579–583 (2000).
Kwon, Y.T. et al. Science 297, 96–99 (2002).
Du, F., Navarro-Garcia, F., Xia, Z., Tasaki, T. & Varshavsky, A. Proc. Natl Acad. Sci. USA 99, 14110–14115 (2002).
Kwon, Y.T. et al. Mol. Cell. Biol. 20, 4135–4148 (2000).
Rao, H., Uhlmann, F., Nasmyth, K. & Varshavsky, A. Nature 410, 955–960 (2001).
Hauf, S., Waizenegger, I.C. & Peters, J.-M. Science 293, 1320–1323 (2001).
Deveraux, Q.L. et al. EMBO J. 18, 5242–5251 (1999).
Algeciras-Schimnich, A., Barnhart, B.C. & Peter, M.E. Curr. Opin. Cell Biol. 14, 721–726 (2002).
Balzi, E., Choder, M., Chen, W., Varshavsky, A. & Goffeau, A. J. Biol. Chem. 265, 7464–7471 (1990).
Yoshida, S., Ito, M., Gallis, J., Nishida, I. & Watanabe, A. Plant J. 32, 129–137 (2002).
Davydov, I.V. & Varshavsky, A. J. Biol. Chem. 275, 22931–22941 (2000).
Kwon, Y.T., Xia, Z., Davydov, I.V., Lecker, S.H. & Varshavsky, A. Mol. Cell. Biol. 21, 8007–8021 (2001).
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Varshavsky, A. The N-end rule and regulation of apoptosis. Nat Cell Biol 5, 373–376 (2003). https://doi.org/10.1038/ncb0503-373
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DOI: https://doi.org/10.1038/ncb0503-373
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