Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Vaccine Technology: Adjuvants for Increased Efficacy

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ellouz, F., Adam, A., Ciorbaru, R. and Lederer, E. 1974. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem. Biophys. Res. Comm. 59: 1317.

    Article  CAS  Google Scholar 

  2. Allison, A.C., Byars, N.E. and Waters, R.V. 1986. Immunologic adjuvants: efficacy and safety considerations, pp. 91–103 In: Advances in Carriers and Adjuvants for Veterinary Biologies. R. M. Nervig, P. M. Gough, M. L. Kaeberle, and C. A. Whetstone (eds.), Iowa State University Press, Ames, Iowa.

    Google Scholar 

  3. Geczy, A.F., Alexander, K., Bashir, H.V., Edmonds, J.P., Upfold, L. and Sullivan, J. 1983. HLA-B27, Klebsiella and ankylosing spondylitis: biological and chemical studies. Immunol. Rev. 70: 23.

    Article  CAS  Google Scholar 

  4. Allison, A.C. and Byars, N.E. 1986. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity. J. Immunol. Methods 95: 157.

    Article  CAS  Google Scholar 

  5. Schmolka, I.R. 1977. A review of block polymer surfactants. J. Am. Oil Chem. Soc. 54: 110.

    Article  CAS  Google Scholar 

  6. Klaus, G.G., Humphrey, J.H., Kunkl, A. and Dongworth, D.W. 1980. The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol. Rev. 53: 3.

    Article  CAS  Google Scholar 

  7. Ron, Y. and Sprent, J. 1987. T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138: 2848.

    CAS  PubMed  Google Scholar 

  8. Braemer, A.C., Allison, A.C., Byars, N.E., Cutting, J.A., Dietrich, D., McRoberts, M. and Renneke, G. 1987. Proceedings of the XIIIth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases, Jerusalem (in press).

  9. Marx, P.A., Pedersen, N.C., Lerche, N.W., Osborn, K.G., Lowenstine, L.J., Lockner, A.A., Maul, D.H., Kwang, H.-S., Kluge, J.D., Zaiss, C.P., Sharpe, V., Spunner, A.P., Allison, A.C. and Gardner, M.B. 1986. Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine. J. Virol. 60: 431.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Letvin, N.L., Mutthiah, D., King, N.W., Kiotaki, M., Chalifaux, L.V., Schegal, P.K., Desrosiers, R.C., Arthur, L.O. and Allison, A.C. 1987. AIDS-like disease in macaque monkeys induced by SIV: a vaccine trial. Vaccines 87, Cold Spring Harbor Press, NY.

  11. Berman, P.W., Gregory, T., Crase, P. and Lasky, L.A. 1985. Protection from genital herpes simplex type 2 infection by vaccination with cloned glycoprotein D. Science 227: 1490.

    Article  CAS  Google Scholar 

  12. Bringman, T.S., Lindquist, P.B. and Derynck, R. 1987. Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursor. Cell 48: 429.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Allison, A., Byars, N. Vaccine Technology: Adjuvants for Increased Efficacy. Nat Biotechnol 5, 1041–1045 (1987). https://doi.org/10.1038/nbt1087-1041

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1087-1041

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing