Elsevier

Kidney International

Volume 83, Issue 6, June 2013, Pages 984-986
Kidney International

Commentary
Autophagy and matrix vesicles: new partners in vascular calcification

https://doi.org/10.1038/ki.2013.75Get rights and content
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Vascular calcification is an actively regulated process driven by vascular smooth muscle cell (VSMC) adaptation and ultimately dysfunction, leading to the induction of active osteogenic processes within the vessel wall. Dai et al., for the first time, identify autophagy as a novel adaptive mechanism that protects against phosphate-induced VSMC calcification, by acting to regulate apoptosis and the release of mineralizing matrix vesicles from VSMCs.

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The author declared no competing interests.