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Prostanoid DP receptor (PTGDR) variants in mothers with post-coital associated preterm births: preliminary observations

Journal of Perinatology volume 30, pages 33–37 (2010)Cite this article

Abstract

Objective:

To describe prostanoid DP receptor (PTGDR) variants in women with preterm births who admitted to coital activity (CA) within 24 h of labor.

Study Design:

To achieve >80% statistical power, a pilot case-control study compared 24 premature births from mothers with CA (Group 1), 30 mothers of premature infants who did not have CA (Group 2 non-coital activity) and 95 non-coital activity mothers with term births (Group 3 controls). Four functional PTDGR single nucleotide polymorphisms (SNPs) were evaluated: T-549C, C-441/T, T-197C and G+1044A. PHASE 2.0.2 and SAS 9.2 were used for analysis.

Result:

All SNPs were in Hardy–Weinberg equilibrium in controls. The C-441/T genotype frequency was significantly increased among Group 1 women relative to Group 2 and 3 women (odds ratio (OR): 30.1, 95% confidence interval (CI) 6.9–191 and 25.7 95%CI 25.7-not computible, respectively). Of the possible haplotypes among the groups, the TCTG haplotype (T-549C, C-441/T, T-197C and G+1044A) was significantly more frequent in Group 1 women compared with the control groups (OR 53.4, 95%CI 10.3–554.8).

Conclusions:

A differential genomic pattern of PTGDR polymorphisms was identified in a sub-set of mothers which was associated with an increased risk of post-coital preterm birth.

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Acknowledgements

The authors would like to acknowledge the contribution of Ms Gaya Chicco of the Gaucher Clinic, Shaare Zedek Medical Center for technical assistance and Prof AI Eidelman for his support and critical review of the manuscript.

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Authors and Affiliations

  1. Departments of Gynecology and Obstetrics, School of Medicine, Hebrew University, Jerusalem, Israel

    S Grisaru-Granovsky, S Finci, A Weintraub, A Tevet & A Samueloff

  2. Departments of Human Genetics, School of Medicine, Hebrew University, Jerusalem, Israel

    G Altarescu

  3. Departments of Neonatology Shaare Zedek Medical Center, the Hebrew University, Jerusalem, Israel

    M S Schimmel

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  1. S Grisaru-Granovsky
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  2. G Altarescu
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  3. S Finci
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  6. A Samueloff
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Correspondence to S Grisaru-Granovsky.

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Presented at the SMFM Annual Meeting, Dallas, Texas, USA 2008

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Grisaru-Granovsky, S., Altarescu, G., Finci, S. et al. Prostanoid DP receptor (PTGDR) variants in mothers with post-coital associated preterm births: preliminary observations. J Perinatol 30, 33–37 (2010). https://doi.org/10.1038/jp.2009.127

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