Abstract
Cyslabdan produced by Streptomyces sp. K04-0144 was found to potentiate imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). The MIC value of imipenem against MRSA was reduced from 16 to 0.015 μg/ml in combination with cyslabdan. Study on anti-MRSA activity of other typical antibiotics in combination with cyslabdan showed that the potentiating activity was limited to β-lactam antibiotics. Furthermore, among β-lactam antibiotics, the activity of carbapenems was most remarkably poteintiated by cyslabdan.
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Fukumoto, A., Kim, YP., Hanaki, H. et al. Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144. J Antibiot 61, 7–10 (2008). https://doi.org/10.1038/ja.2008.102
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DOI: https://doi.org/10.1038/ja.2008.102
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