Abstract
OBJECTIVE:
Short sleep duration and sleep problems increase risks of overweight and weight gain. Few previous studies have examined sleep and weight repeatedly over development. This study examined the associations between yearly reports of sleep problems and weight status from ages 5 to 11. Although, previous studies have shown that inter-individual differences moderate the effect of short sleep duration on weight, it is not known whether inter-individual differences also moderate the effect of sleep problems on weight. We tested how the longitudinal associations between sleep problems and weight status were moderated by impulsivity and genetic variants in DRD2 and ANKK1.
DESIGN:
Seven-year longitudinal study.
PARTICIPANTS:
A total of 567 children from the Child Development Project for the analysis with impulsivity and 363 for the analysis with genetic variants.
MEASUREMENTS and RESULTS:
Sleep problems and weight status were measured by mothers’ reports yearly. Impulsivity was measured by teachers’ reports yearly. Six single-nucleotide polymorphisms located in DRD2 and ANKK1 were genotyped. Data were analyzed using multilevel modeling. Higher average levels of sleep deprivation across years were associated with greater increases in overweight (P=0.0024). Sleep problems and overweight were associated at both within-person across time (P<0.0001) and between-person levels (P<0.0001). Impulsivity and two polymorphisms, rs1799978 and rs4245149 in DRD2, moderated the association between sleep problems and overweight; the association was stronger in children who were more impulsive (P=0.0022), in G allele carriers for rs1799978 (P=0.0007) and in A allele carriers for rs4245149 (P=0.0002).
CONCLUSIONS:
This study provided incremental evidence for the influence of sleep problems on weight. Findings of DRD2, ANKK1 and impulsivity are novel; they suggest that reward sensitivity and self-regulatory abilities might modulate the influences of sleep on weight gain. The analysis of polymorphisms was restricted to European Americans and hence the results might not generalize to other populations.
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References
Lyytikainen P, Lallukka T, Lahelma E, Rahkonen O . Sleep problems and major weight gain: a follow-up study. Int J Obesity 2011; 35: 109–114.
Knutson KL, Cauter E . Associations between sleep loss and increased risk of obesity and diabetes. Ann Ny Acad Sci 2008; 1129: 287–304.
Nielsen LS, Danielsen KV, Sorensen TIA . Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence. Obes Rev 2011; 12: 78–92.
Horne J . Obesity and short sleep: unlikely bedfellows? Obes Rev 2011; 12: e84–e94.
Chaput JP, Despres JP, Bouchard C, Tremblay A . The association between short sleep duration and weight gain is dependent on disinhibited eating behavior in adults. Sleep 2011; 34: 1291–1297.
Prats-Puig A, Grau-Cabrera P, Riera-Perez E, Cortes-Marina R, Fortea E, Soriano-Rodriguez P et al. Variations in the obesity genes FTO, TMEM18 and NRXN3 influence the vulnerability of children to weight gain induced by short sleep duration. Int J Obes (Lond) 2012; 37: 182–187.
Brondel L, Romer MA, Nougues PM, Touyarou P, Davenne D . Acute partial sleep deprivation increases food intake in healthy men. Am J Clin Nutr 2010; 91: 1550–1559.
Nedeltcheva AV, Kilkus JM, Imperial J, Kasza K, Schoeller DA, Penev PD . Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr 2009; 89: 126–133.
Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Benedict C, Lehnert H et al. Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am J Clin Nutr 2009; 90: 1476–1482.
Gujar N, Yoo SS, Hu P, Walker MP . Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences. J Neurosci 2011; 31: 4466–4474.
Holm SM, Forbes EE, Ryan ND, Phillips ML, Tarr JA, Dahl RE . Reward-related brain function and sleep in pre/early pubertal and mid/late pubertal adolescents. J Adolescent Health 2009; 45: 326–334.
Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Wong C et al. Sleep deprivation decreases binding of [C-11]raclopride to dopamine D-2/D-3 receptors in the human brain. J Neurosci 2008; 28: 8454–8461.
Noble EP, Noble RE, Ritchie T, Grandy DK, Sparkes RS . Allelic association of the D2 dopamine-receptor gene with obesity. Am J Hum Genet 1993; 53: 117.
Noble EP, Noble RE, Ritchie T, Syndulko K, Bohlman MC, Noble LA et al. D(2) dopamine-receptor gene and obesity. Int J Eat Disorder 1994; 15: 205–217.
Dick DM, Wang JC, Plunkett J, Aliev F, Hinrichs A, Bertelsen S et al. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcohol Clin Exp Res 2007; 31: 1645–1653.
Nederkoorn C, Jansen E, Mulkens S, Jansen A . Impulsivity predicts treatment outcome in obese children. Behav Res Ther 2007; 45: 1071–1075.
Wasser H, Bentley M, Borja J, Goldman BD, Thompson A, Slining M et al. Infants perceived as ‘fussy’ are more likely to receive complementary foods before 4 months. Pediatrics 2011; 127: 229–237.
Stifter CA, Anzman-Frasca S, Birch LL, Voegtline K . Parent use of food to soothe infant/toddler distress and child weight status. An exploratory study. Appetite 2011; 57: 693–699.
Dodge KA, Bates JE, Pettit GS . Mechanisms in the cycle of violence. Science 1990; 250: 1678–1683.
Dodge KA, Pettit GS, Bates JE . Socialization mediators of the relation between socioeconomic-status and child conduct problems. Child Dev 1994; 65: 649–665.
Achenbach TM . Multidimensional description of child-personality - a manual for the personality-inventory for children—Wirt,Rd, Lachar,D, Kleindinst,Jk, Seat,Pd. J Pers Assess 1981; 45: 332–333.
Herman KM, Craig CL, Gauvin L, Katzmarzyk PT . Tracking of obesity and physical activity from childhood to adulthood: the Physical Activity Longitudinal Study. Int J Pediatr Obes 2009; 4: 281–288.
Boutelle K, Fulkerson JA, Neumark-Sztainer D, Story M . Mothers' perceptions of their adolescents' weight status: are they accurate? Obes Res 2004; 12: 1754–1757.
Aronen ET, Paavonen EJ, Fjallberg M, Soininen M, Torronen J . Sleep and psychiatric symptoms in school-age children. J Am Acad Child Psy 2000; 39: 502–508.
Gregory AM, O'Connor TG . Sleep problems in childhood: a longitudinal study of developmental change and association with behavioral problems. J Am Acad Child Psy 2002; 41: 8.
Goodnight JA, Bates JE, Staples AD, Pettit GS, Dodge KA . Temperamental resistance to control increases the association between sleep problems and externalizing behavior development. J Fam Psychol 2007; 21: 39–48.
Barrett JC, Fry B, Maller J, Daly MJ . Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263–265.
Achenbach T . Integrative Guide for the 1991 CBCL 14-18, YSR, and TRF Profiles.. University of Vermont, Department of Psychiatry: Burlington, VT, USA, 1991.
Enders CK, Tofighi D . Centering predictor variables in cross-sectional multilevel models: a new look at an old issue. Psychol Methods 2007; 12: 121–138.
Snell EK, Adam EK, Duncan GJ . Sleep and the body mass index and overweight status of children and adolescents. Child Dev 2007; 78: 309–323.
Touchette E, Petit D, Tremblay RE, Boivin M, Falissard B, Genolini C et al. Associations between sleep duration patterns and overweight/obesity at age 6. Sleep 2008; 31: 1507–1514.
Chaput JP, Brunet M, Tremblay A . Relationship between short sleeping hours and childhood overweight/obesity: results from the 'Quebec en Forme' Project. Int J Obesity 2006; 30: 1080–1085.
Chaput JP, Despres JP, Bouchard C, Tremblay A . The association between sleep duration and weight gain in adults: a 6-year prospective study from the Quebec Family Study. Int J Obesity 2008; 32: S35–S35.
Montplaisir J, Touchette E, Petit D, Boivin M, Tremblay R . Short sleep duration and risk of obesity in early childhood—a longitudinal study. Sleep 2007; 30: A101–A102.
Seegers V, Petit D, Falissard B, Vitaro F, Tremblay RE, Montplaisir J et al. Short sleep duration and body mass index: a prospective longitudinal study in preadolescence. Am J Epidemiol 2011; 173: 621–629.
Al Mamun A, Lawlor DA, Cramb S, O'Callaghan M, Williams G, Najman J . Do childhood sleeping problems predict obesity in young adulthood? Evidence from a prospective birth cohort study. Am J Epidemiol 2007; 166: 1368–1373.
Pesonen AK, Raikkonen K, Paavonen EJ, Heinonen K, Komsi N, Lahti J et al. Sleep duration and regularity are associated with behavioral problems in 8-year-old children. Int J Behav Med 2011; 17: 298–305.
Dewald JF, Meijer AM, Oort FJ, Kerkhof GA, Bogels SM . The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: a meta-analytic review. Sleep Med Rev 2010; 14: 179–189.
Knutson KL, Ryden AM, Mander BA, Van Cauter E . Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Arch Intern Med 2006; 166: 1768–1774.
Hoevenaar-Blom MP, Spijkerman AMW, Kromhout D, van den Berg JF, Verschuren WMM . Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN Study. Sleep 2011; 34: 1487–1492.
Chaput JP . Short sleep duration promoting overconsumption of food: a reward-driven eating behavior? Commentary on Weiss et al. The association of sleep duration to adolescents' fat and carbohydrate consumption. SLEEP 2010;33:1201-1209. Sleep 2010 33: 1135–1136.
Knutson KL, Spiegel K, Penev P, Van Cauter E . The metabolic consequences of sleep deprivation. Sleep Med Rev 2007; 11: 163–178.
Spiegel K, Tasali E, Penev P, Van Cauter E . Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004; 141: 846–850.
Spiegel K, Tasali E, Leproult R, Van Cauter E . Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev Endocrinol 2009; 5: 253–261.
Taheri S, Lin L, Austin D, Young T, Mignot E . Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. Plos Med 2004; 1: 210–217.
Zirlik S, Hauck T, Fuchs FS, Neurath MF, Konturek PC, Harsch IA . Leptin, obestatin and apelin levels in patients with obstructive sleep apnoea syndrome. Med Sci Monitor 2011; 17: Cr159–Cr164.
Spiegel K, Leproult R, L'Hermite-Baleriaux M, Copinschi G, Penev PD, Van Cauter E . Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocr Metab 2004; 89: 5762–5771.
Dahl RE . The regulation of sleep and arousal: development and psychopathology. Dev Psychopathol 1996; 8: 3–27.
Anderson C, Platten CR . Sleep deprivation lowers inhibition and enhances impulsivity to negative stimuli. Behav Brain Res 2011; 217: 463–466.
Cappuccio F . Short sleep duration and obesity: evidence from population-based studies in children, adolescents and adults across the world. Sleep 2007; 30: A129–A129.
Chen XL, Beydoun MA, Wang YF . Is sleep duration associated with childhood obesity? A systematic review and meta-analysis. Obesity 2008; 16: 265–274.
Patel SR, Hu FB . Short sleep duration and weight gain: a systematic review. Obesity 2008; 16: 643–653.
Hart CN, Jelalian E . Shortened sleep duration is associated with pediatric overweight. Behav Sleep Med 2008; 6: 251–267.
Van Cauter E, Knutson KL . Sleep and the epidemic of obesity in children and adults. Eur J Endocrinol 2008; 159: S59–S66.
Marshall NS, Glozier N, Grunstein RR . Is sleep duration related to obesity? A critical review of the epidemiological evidence. Sleep Med Rev 2008; 12: 289–298.
R Core Team. (2013) R: A language and environment for statistical computing. R Foundation for Statistical Computing: Vienna, Austria ISBN 3-900051-07-0 http://www.R-project.org/.
Acknowledgements
The Child Development Project has been funded by National Institute of Mental Health Grants MH42498, MH56961, MH57024 and MH57095; Eunice Kennedy Shriver National Institute of Child Health and Human Development Grant HD30572; and National Institute on Drug Abuse Grant DA016903. We thank John Budde and Dr Alison Goate for their contribution to this project through DNA extraction and genotyping of the initial set of genetic markers. We also thank Dr Leslie Rutkowski and Ms Stephanie Dickenson for their advice on statistical analysis.
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Chan, T., Bates, J., Lansford, J. et al. Impulsivity and genetic variants in DRD2 and ANKK1 moderate longitudinal associations between sleep problems and overweight from ages 5 to 11. Int J Obes 38, 404–410 (2014). https://doi.org/10.1038/ijo.2013.123
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DOI: https://doi.org/10.1038/ijo.2013.123
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