Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Reovirus infection of cancer cells is not due to activated Ras pathway

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Coffey MC, Strong JE, Forsyth PA, Lee PW . Reovirus therapy of tumors with activated Ras pathway. Science 1998; 282: 1332–1334.

    Article  CAS  Google Scholar 

  2. Strong JE, Coffey MC, Tang D, Sabinin P, Lee PW . The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus. EMBO J 1998; 17: 3351–3362.

    Article  CAS  Google Scholar 

  3. Jainchill JL, Aaronson SA, Todaro GJ . Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. J Virol 1969; 4: 549–553.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Hull RN, Cherry WR, Johnson IS . The adaptation and maintenance of mammalian cells to continuous growth in tissue culture. Anat Rec 1956; 124: 490–499.

    Google Scholar 

  5. Stanford KK, Etrie WR, Likely GD . The growth in vitro of single isolated tissue cells. J Natl Cancer Inst 1948; 9: 229–246.

    Google Scholar 

  6. Song LT, Gelman I, Holland JF, Ohnuma T . Study of reovirus-induced cytopathic effect (CPE), ras, double-stranded RNA-activated protein kinase (PKR) and eIF2α in human tumor cell lines. Proc Am Assoc Cancer Res 2000; 41: 350.

    Google Scholar 

  7. van Houdt WJ, Smakman N, van den Wollenberg DJ, Emmink BL, Veenendaal LM, van Diest PJ et al. Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles. Cancer Gene Ther 2008; 15: 284–292.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to L Song.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Song, L., Ohnuma, T., Gelman, I. et al. Reovirus infection of cancer cells is not due to activated Ras pathway. Cancer Gene Ther 16, 382 (2009). https://doi.org/10.1038/cgt.2008.84

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/cgt.2008.84

This article is cited by

Search

Quick links