Abstract
The derivation of the median volume (MV) and the geometric standard deviation (SDg) for a suspension of tumour cells quantifies the size and distribution of tumour cell aggregates in the suspension. Data collected in a group of 14 experiments shwoed a significant correlation of 0.80 (P less than 0.001) between the number of lung tumours formed by a suspension of B16 melanoma cells injected i.v. into C57BL/6J mice and the product of the MV and SDg of each cell suspension. These data define a size parameter of tumour cell suspensions that correlates with the intravascular survival properties of tumour cells.
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Lione, A., Bosmann, H. Quantitative relationship between volume of tumour cell units and their intravascular survival. Br J Cancer 37, 248–253 (1978). https://doi.org/10.1038/bjc.1978.33
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DOI: https://doi.org/10.1038/bjc.1978.33
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