Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The path not taken

Nature Biotechnology volume 19, pages 626–627 (2001)Cite this article

If known pathways represent preferred paths through global protein networks, large-scale experiments should focus on how to recognize these paths among all of the alternatives.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: How do our traditional genetic and biochemical pathways measure up to the observed global co-expression and interaction networks?

References

  1. Idekar, T. et al. Science 292, 929–934 (2001).

    Article  Google Scholar 

  2. Gygi, S.P., Rochon, Y., Franza, B.R. & Aebersold, R. Mol. Cell. Biol. 19, 1720–1730 (1999).

    Article  CAS  Google Scholar 

  3. Pasternack, L.B., Laude, D.A. Jr. & Appling, D.R. Biochemistry 33, 7166–7173 (1994).

    Article  CAS  Google Scholar 

  4. Fiehn, O. et al. Nat. Biotechnol. 18, 1157–1161 (2000).

    Article  CAS  Google Scholar 

  5. Uetz, P. et al. Nature 403, 623–627 (2000).

    Article  CAS  Google Scholar 

  6. Ito, T. et al. Proc. Natl. Acad. Sci. USA 98, 4569–4574 (2001).

    Article  CAS  Google Scholar 

  7. Xenarios, I., et al. Nucleic Acids Res. 29, 239–241 (2001).

    Article  CAS  Google Scholar 

  8. Marcotte, E.M., Pellegrini, M., Thompson, M.J., Yeates, T.O. & Eisenberg. D. Nature 402, 83–86 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry & Institute of Cell and Molecular Biology, 2500 Speedway

    Edward M. Marcotte

  2. University of Texas, Austin, 78712, TX

    Edward M. Marcotte

Authors
  1. Edward M. Marcotte
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marcotte, E. The path not taken. Nat Biotechnol 19, 626–627 (2001). https://doi.org/10.1038/90222

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/90222

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing