Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metabolic syndrome

F stands for fructose and fat

Nature volume 502, pages 181–182 (2013)Cite this article

Subjects

Fructose and glucose have the same caloric value, but the two sugars are metabolized differently. It emerges that mice that cannot metabolize fructose are healthier when placed on carbohydrate-rich diets.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Sugar metabolism.

References

  1. Lustig, R. H. J. Am. Diet. Assoc. 110, 1307–1321 (2010).

    Article  CAS  Google Scholar 

  2. Feinman, R. D. & Fine, E. J. Nutr. Metab. 10, 45 (2013).

    Article  CAS  Google Scholar 

  3. Ishimoto, T. et al. Hepatology http://dx.doi.org/10.1002/hep.26594 (2013).

  4. Lanaspa, M. A. et al. Nature Commun. 4, 2434 (2013).

    Article  ADS  Google Scholar 

  5. Ventura, E. E., Davis, J. N. & Goran, M. I. Obesity 19, 868–874 (2011).

    Article  CAS  Google Scholar 

  6. Stanhope, K. L. et al. J. Clin. Invest. 119, 1322–1334 (2009).

    Article  CAS  Google Scholar 

  7. Khandekar, M. J., Cohen, P. & Spiegelman, B. M. Nature Rev. Cancer 11, 886–895 (2011).

    Article  CAS  Google Scholar 

  8. Dhingra, R. et al. Circulation 116, 480–488 (2007).

    Article  Google Scholar 

  9. Teff, K. L. et al. J. Clin. Endocrinol. Metab. 94, 1562–1569 (2009).

    Article  CAS  Google Scholar 

  10. Jürgens, H. et al. Obes. Res. 13, 1146–1156 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Costas A. Lyssiotis and Lewis C. Cantley are in the Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA.,

    Costas A. Lyssiotis & Lewis C. Cantley

Authors
  1. Costas A. Lyssiotis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lewis C. Cantley
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Costas A. Lyssiotis or Lewis C. Cantley.

Ethics declarations

Competing interests

L.C.C. owns equity in, receives compensation from, and serves on the Board of Directors and Scientific Advisory Board of Agios Pharmaceuticals. Agios Pharmaceuticals is identifying metabolic pathways of cancer cells and developing drugs to inhibit such enzymes in order to disrupt tumour-cell growth and survival.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lyssiotis, C., Cantley, L. F stands for fructose and fat. Nature 502, 181–182 (2013). https://doi.org/10.1038/502181a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/502181a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing