Chronic drug use can lead to addiction, which is initiated by specific brain circuits. The mystery of how one class of drugs, the benzodiazepines, affects activity in this circuitry has finally been solved.
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References
Tan, K. R. et al. Nature 463, 769–774 (2010).
Heikkinen, A. E., Möykkynen, T. P. & Korpi, E. R. Neuropsychopharmacology 34, 290–298 (2009).
Johnson, S. W. & North, R. A. J. Neurosci. 12, 483–488 (1992).
Nelson, S. B. & Turrigiano, G. G. Neuron 60, 477–482 (2008).
Turrigiano, G. G. Cell 135, 422–435 (2008).
Hajak, G., Müller, W. E., Wittchen, H. U., Pittrow, D. & Kirch, W. Addiction 98, 1371–1378 (2003).
Rowlett, J. K., Platt, D. M., Lelas, S., Atack, J. R. & Dawson, G. R. Proc. Natl Acad. Sci. USA 102, 915–920 (2005).
McKernan, R. M. et al. Nature Neurosci. 3, 587–592 (2000).
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Riegel, A., Kalivas, P. Lack of inhibition leads to abuse. Nature 463, 743–744 (2010). https://doi.org/10.1038/463743a
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DOI: https://doi.org/10.1038/463743a
