Abstract
MAJOR histocompatibility complex (MHC) class I molecules present endogenous antigens to CD8+ (cytotoxic) T cells. MHC class II molecules present primarily exogenously derived antigens to CD4+ T cells. Three new genes (Ma, Mbl and Mb2) located between the Pb and Ob genes of the murine MHC have properties indicating that they are members of the MHC class II gene family, but they are the most divergent class II members so far identified and are almost as closely related in sequence to class I genes as they are to the known class II genes.
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Cho, S., Attaya, M. & Monaco, J. New class ll-like genes in the murine MHC. Nature 353, 573–576 (1991). https://doi.org/10.1038/353573a0
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DOI: https://doi.org/10.1038/353573a0
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