Abstract
Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles ofHLA-DQβ determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the β-chain, specifies the autoimmune response against the insulin-producing islet cells.
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Todd, J., Bell, J. & McDevitt, H. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329, 599–604 (1987). https://doi.org/10.1038/329599a0
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DOI: https://doi.org/10.1038/329599a0
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