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HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

Abstract

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles ofHLA-DQβ determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the β-chain, specifies the autoimmune response against the insulin-producing islet cells.

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References

  1. Svejgaard, A., Platz, P. & Ryder, L. P. Immun. Rev. 70, 193–218 (1983).

    Article  CAS  Google Scholar 

  2. Kaufman, J. F., Auffray, C., Korman, A. J., Shackelford, D. A. & Strominger, J. L. Cell 36, 1–13 (1984).

    Article  CAS  Google Scholar 

  3. Sette, A., Buus, S., Colon, S., Smith, J. A., Miles, C. & Grey, H. Nature 328, 395–399 (1987).

    Article  ADS  CAS  Google Scholar 

  4. Germain, R. N. & Malissen, B. A. Rev. Immun. 4, 281–315 (1986).

    Article  CAS  Google Scholar 

  5. Cairns, J. S. et al. Nature 317, 166–168 (1985).

    Article  ADS  CAS  Google Scholar 

  6. Rossini, A. A., Mordes, J. P. & Like, A. A. A. Rev. Immun. 3, 289–320 (1985).

    Article  CAS  Google Scholar 

  7. Thomson, G. Am. J. hum. Genet. 36, 1309–1317 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Rotter, J. I. & Landlaw, E. M. Clin. Genet. 26, 529–542 (1984).

    Article  CAS  Google Scholar 

  9. Winter W. E. et al. New Engl. J. Med. 316, 285–291 (1987).

    Article  CAS  Google Scholar 

  10. Rich S. S., Weitkamp, L. R. & Barbosa, J. Am. J. hum. Genet. 36, 1015–1023 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Winearls, B. C. et al. Tissue Antigens 24, 234–246 (1984).

    Article  CAS  Google Scholar 

  12. De Jongh, B. M., Termijtelen, A., Bruining, G. J., De Vries, R. R. P. & Van Rood, J. J. Tissue Antigens 23, 87–93 (1984).

    Article  CAS  Google Scholar 

  13. Rubinstein, P., Ginsberg-Fellner, F. & Falk, C., Am. J. Hum. Genet. 33, 865–882 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Bertrams, J. & Baur, M. P. in Histocompatibility Testing (eds Albert, E. D., Baur, M. P. & Mayr, W. R.) 348–358 (Springer, Berlin, 1984).

    Google Scholar 

  15. Kim, S. J. et al. Proc. natn. Acad. Sci. U.S.A. 82, 8139–8143 (1985).

    Article  ADS  CAS  Google Scholar 

  16. Schreuder, G. M. T. et al. J. exp. Med. 164, 938–943 (1986).

    Article  CAS  Google Scholar 

  17. Owerbach, D. et al. Nature 303, 815–817 (1983).

    Article  ADS  CAS  Google Scholar 

  18. Cohen-Haguenauer, O. et al. Proc. natn. Acad. Sci. U.S.A. 82, 3335–3339 (1985).

    Article  ADS  CAS  Google Scholar 

  19. Arnheim, N., Strange, C. & Erlich, H. Proc. natn. Acad. Sci. U.S.A. 82, 6970–6974 (1985).

    Article  ADS  CAS  Google Scholar 

  20. Bohme, J. et al. J. Immunol. 137, 941–947 (1986).

    CAS  PubMed  Google Scholar 

  21. Nepom, B. S. et al. J. exp. Med. 164, 345–350 (1986).

    Article  CAS  Google Scholar 

  22. Segall, M. et al. Hum. Immunol. 17, 61–68 (1986).

    Article  CAS  Google Scholar 

  23. Festenstein, H. et al. Nature 322, 64–67 (1986).

    Article  ADS  CAS  Google Scholar 

  24. Scharf, S. J., Horn, G. T. & Erlich, H. A. Science 233, 1076–1078 (1986).

    Article  ADS  CAS  Google Scholar 

  25. Saiki, R. K., Bugawan, T. L., Horn, G. T., Mullis, K. B. & Erlich, H. A. Nature 324, 163–166 (1986).

    Article  ADS  CAS  Google Scholar 

  26. Acha-Orbea, H. & McDevitt, H. O. Proc. natn. Acad. Sci. U.S.A. 84, 2435–2439 (1987).

    Article  ADS  CAS  Google Scholar 

  27. Hardy, D. A., Bell, J. I., Long, E. O., Lindsten, T. & McDevitt, H. O. Nature 323, 453–455 (1986).

    Article  ADS  CAS  Google Scholar 

  28. Schreuder, G. M. T., Doxiadis, I., Parlevliet, J. & Grosse-Wilde, H. in Histocompatibilily Testing (eds Albert, E. D., Baur, M. P. & Mayr, W. R. ) 243–248 (Springer, Berlin, 1984).

    Google Scholar 

  29. Matsuki, K., Juji, T. & Satake, M. Hum. Immun. 18, 247–256 (1987).

    Article  CAS  Google Scholar 

  30. Maeda, H., Hirata, R., Thompson, A. & Mukai, R. Hum. Immun. 15, 1–15 (1986).

    Article  CAS  Google Scholar 

  31. Bach, F. H., Ohta, N., Anichini, A. & Reinsmoen, N. L. in HLA Class II Antigens (eds Solheim, B. G., Moller, E. & Ferrone, S. ) 249–265 (Springer, Berlin, 1986).

    Book  Google Scholar 

  32. Baur, M. P., Naugebauer, M. & Albert, E. D. in Histocompatibilitv Testing (eds Albert, E. D., Baur, M. P. & Mayr, W. R.) 677–760 (Springer, Berlin, 1984).

    Google Scholar 

  33. Tanigaki, N., Tosi, R., Centis, D. & Ferrara, G. B. Hum. Immun. 12, 47–57 (1985).

    Article  CAS  Google Scholar 

  34. Michelsen, B. & Lernmark, A. J. clin. Invest. 79, 1144–1152 (1987).

    Article  CAS  Google Scholar 

  35. Cohen, N., Brautbar, C., Font, M.P., Dausset, J. & Cohen, D. Immunogenetics 23, 84–89 (1986).

    Article  CAS  Google Scholar 

  36. Moriuchi, J., Moriuchi, T. & Silver, J. Proc. natn. Acad. Sci. U.S.A. 82, 3420–3424 (1985).

    Article  ADS  CAS  Google Scholar 

  37. Wicker, L. S. et al. J. exp. Med. 165, 1639–1654 (1987).

    Article  CAS  Google Scholar 

  38. Estess, P., Begovich, A. B., Koo, M., Jones, P. P. & McDevitt, H. O. Proc. natn. Acad. Sci. U.S.A. 83, 3594–3598 (1986).

    Article  ADS  CAS  Google Scholar 

  39. Gregersen, P. K. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2642–2646 (1986).

    Article  ADS  CAS  Google Scholar 

  40. Larhammar, D. et al. Proc. natn. Acad. Sci. U.S.A. 80, 7313–7317 (1983).

    Article  ADS  CAS  Google Scholar 

  41. Long, E. O., Wake, C. T., Gorski, J. & Mach, B. EMBO J. 2, 389–394 (1983).

    Article  CAS  Google Scholar 

  42. Todd, J. A. et al. J. Bact. 167, 257–264 (1986).

    Article  CAS  Google Scholar 

  43. Spies, T., Sorrentino, R., Boss, J. M., Okada, K. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 82, 5165–5169 (1985).

    Article  ADS  CAS  Google Scholar 

  44. Rollini, P., Mach, B. & Gorski, J. Proc. natn. Acad. Sci. U.S.A. 82, 7197–7201 (1985).

    Article  ADS  CAS  Google Scholar 

  45. Bell, J. I. et al. Proc. natn. Acad. Sci. U.S.A. 84, 6234–6238 (1987).

    Article  ADS  CAS  Google Scholar 

  46. Auflray, C. et al. Nature 308, 327–333 (1984).

    Article  ADS  Google Scholar 

  47. Okada, K. et al. Proc. natn. Acad. Sci. U.S.A. 82, 3410–3414 (1985).

    Article  ADS  CAS  Google Scholar 

  48. Tonnelle, C., DeMars, R. & Long, E. O. EMBO J. 4, 2839–2847 (1985).

    Article  CAS  Google Scholar 

  49. Lee, B. S. M., Rust, N. A., McMichael, A. J. & McDevitt, H. O. Proc. natn. Acad. Sci. U.S.A. 84, 4591–4595 (1987).

    Article  ADS  CAS  Google Scholar 

  50. Wu, S., Saunders, T. L. & Bach, F. H. Nature 324, 676–679 (1986).

    Article  ADS  CAS  Google Scholar 

  51. Gorski, J. & Mach, B. Nature 322, 67–70 (1986).

    Article  ADS  CAS  Google Scholar 

  52. Tieber, V. L., Abruzzini, L. F., Didier, D. K., Schwartz, B. D. & Rotwein, P. J. biol. Chem. 261, 2738–2742 (1986).

    CAS  PubMed  Google Scholar 

  53. Freeman, S. M. et al. Hum. Immun. 19, 1–6 (1987).

    Article  CAS  Google Scholar 

  54. Gubler, U. & Hoffman, B. J. Gene 25, 263–269 (1983).

    Article  CAS  Google Scholar 

  55. Waye, M. M. Y., Verhoeyen, M. E., Jones, P. T. & Winter, G. Nucleic Acids Res. 13, 8561–8571 (1985).

    Article  CAS  Google Scholar 

  56. Schenning, L. et al. EMBO J. 3, 447–452 (1984).

    Article  CAS  Google Scholar 

  57. Lee, B. S. M., Bell, J. I., Rust, N. A. & McDevitt, H. O. Immunogenetics 26, 85–91 (1987).

    Article  CAS  Google Scholar 

  58. Boss, J. M. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 81, 5199–5203 (1984).

    Article  ADS  CAS  Google Scholar 

  59. Karr, R. W. et al. J. Immunol. 137, 2886–2890 (1986).

    CAS  PubMed  Google Scholar 

  60. Turco, E. et al. Immunogenetics (in the press).

Download references

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Todd, J., Bell, J. & McDevitt, H. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329, 599–604 (1987). https://doi.org/10.1038/329599a0

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