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The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

Nature volume 329, pages 131–134 (1987)Cite this article

Abstract

The RAD6 gene of the yeast Saccharomyces cerevisiae is required for a variety of cellular functions including DNA repair. The discovery that the RAD6 gene product can catalyse the covalent attachment of ubiquitin to other proteins suggests that the multiple functions of the RAD6 protein are mediated by its ubiquitin-conjugating activity.

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Stefan Jentsch, John P. McGrath & Alexander Varshavsky

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  1. Stefan Jentsch
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  2. John P. McGrath
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  3. Alexander Varshavsky
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Jentsch, S., McGrath, J. & Varshavsky, A. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature 329, 131–134 (1987). https://doi.org/10.1038/329131a0

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