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Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution

Nature volume 311, pages 119–123 (1984)Cite this article

Abstract

DXYS1, a site showing greater than 99% DNA sequence homology between the human X and Y chromosomes, maps to the X long arm and to the Y short arm. In great apes, sequences homologous to DXYS1 are found only on the X chromosome. These findings suggest an X–Y transposition during human evolution.

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Author notes

  1. David C. Page

    Present address: Whiteside Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, 02142, USA

  2. Mary E. Harper

    Present address: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland, 20205, USA

Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    David C. Page & David Botstein

  2. The Agouron Institute, 505 Coast Boulevard South, La Jolla, California, 92037, USA

    Mary E. Harper & Jamie Love

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  1. David C. Page
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  2. Mary E. Harper
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  3. Jamie Love
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  4. David Botstein
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Page, D., Harper, M., Love, J. et al. Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution. Nature 311, 119–123 (1984). https://doi.org/10.1038/311119a0

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