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Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin

Nature volume 301, pages 120–125 (1983)Cite this article

Abstract

The set of histone genes that are active late in embryogenesis of the sea urchin (Strongylocentrotus purpuratus) are present in 5–12 copies per genome and, unlike the clustered, tandemly arrayed early histone genes, are dispersed and irregularly arranged. Late H2B gene expression is activated by events accompanying fertilization and its mRNAs are first detectable by as early as 6 h of development (16 cells) and increase only slightly in amount during the period of rapid cleavage between 6 and 14 h. However, during the short interval between 14 and 16 h, while the amount of early histone mRNA is declining, there is a >15-fold burst in the rate of late H2B mRNA accumulation.

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Author notes

  1. Timothy Mohun

    Present address: Medical Research Council, Laboratory of Molecular Biology, The Medical School, Hills Road, Cambridge, CB2 2QH, UK

  2. Geoffrey Childs

    Present address: Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, 10461, USA

Authors and Affiliations

  1. Department of Medicine, Stanford University School of Medicine and Veterans Administration Medical Center, Palo Alto, California, 94305, USA

    Robert Maxson, Timothy Mohun, Glen Gormezano, Geoffrey Childs & Larry Kedes

Authors
  1. Robert Maxson
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  2. Timothy Mohun
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  3. Glen Gormezano
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  4. Geoffrey Childs
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  5. Larry Kedes
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Maxson, R., Mohun, T., Gormezano, G. et al. Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin. Nature 301, 120–125 (1983). https://doi.org/10.1038/301120a0

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