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Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

Nature volume 299, pages 640–644 (1982)Cite this article

Abstract

The acutely oncogenic retroviruses induce a wide spectrum of malignancies including sarcomas, carcinomas, lymphomas and leukaemias1. They all contain sequences which are required for neoplastic transformation as an integral part of their genomes1–3. These sequences, termed viral oncogenes (v-onc), apparently originated from the normal vertebrate genome.To date, cellular homologues of over a dozen different oncogenes of acutely oncogenic viruses have been identified1–4. Although transcription of some c-onc genes has been detected in normal vertebrate cells1,5–7, relatively little is known about their role in normal cell metabolism. We describe here stage- and tissue-specific expression of cellular genes homologous to the oncogenes of FBJ murine osteosarcoma virus, Abelson imirine leukaemia virus and Harvey sarcoma virus during mouse prenatal and early postnatal development. Our results suggest participation of cellular oncogenes in normal developmental processes.

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References

  1. Weiss, A., Teich, N. M., Varmus, H., & Coffin, J. M. (eds) RNA Tumor Viruses. The Molecular Biology of Tumor Viruses Part III (Cold Spring Harbor Monograph 10C, Cold Spring Harbor, New York 1982).

  2. Bishop, J. M. Scient. Am. 246, 68–78 (1982).

    Article  Google Scholar 

  3. Coffin, J. M. et al. J. Virol. 40, 953–957 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Bishop, J. M. A. Rev. Biochem. 47, 35–88 (1978).

    Article  CAS  Google Scholar 

  5. Chen, J. H. J. Virol. 36, 162–170 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Shibuya, M., Hanafusa, H. & Balduzzi, P. L. J. Virol. 42, 143–152 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Gonda, T. J., Sheiness, D. K. & Bishop, J. M. Molec. cell. Biol. 2, 617–624 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Finkle, M. P., Biskis, B. O. & Jinkins, P. B. Science 151, 698–701 (1966).

    Article  ADS  Google Scholar 

  9. Finkel, M. P. & Biskis, B. O. Prog. exp. Tumor Res. 10, 72–111 (1968).

    Article  CAS  Google Scholar 

  10. Curran, T. & Teich, N. M. J. Virol. 42, 114–122 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Curran, T., Peters, G., Van Beveren, C., Teich, N. M. & Verma, I. M. J. Virol. (in the press).

  12. Abelson, H. T. & Rabstein, L. S. Cancer Res. 30, 2208–2212 (1970).

    CAS  PubMed  Google Scholar 

  13. Cook, W. D. Proc. natn. Acad. Sci. U.S.A. 79, 2917–2921 (1982).

    Article  ADS  CAS  Google Scholar 

  14. Witte, O. N. et al. Proc. natn. Acad. Sci. U.S.A. 75, 2488–2492 (1978).

    Article  ADS  CAS  Google Scholar 

  15. Witte, O. N., Rosenberg, N. E. & Baltimore, D. Nature 281, 396–398 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Harvey, J. J. Nature 204, 1104–1105 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. DeFeo, D. et al. Proc. natn. Acad. Sci. U.S.A. 78, 3328–3332 (1981).

    Article  ADS  CAS  Google Scholar 

  18. Langbeheim, H., Shih, T. Y. & Scolnick, E. M. Virology 106, 292–300 (1980).

    Article  CAS  PubMed  Google Scholar 

  19. Scolnick, E. M. et al. Molec. cell. Biol. 1, 66–74 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Moloney, J. B. Natn. Cancer Inst. Monogr. 22, 139–142 (1966).

    CAS  Google Scholar 

  21. Frankel, A. E. & Fischinger, P. J. Proc. natn. Acad. Sci. U.S.A. 73, 3705–3709 (1976).

    Article  ADS  CAS  Google Scholar 

  22. Gattoni, S. et al. Molec. cell. Biol. 2, 42–51 (1981).

    Article  Google Scholar 

  23. Kirby, D. R. S. in Early Conceptus, Normal and Abnormal (ed. Park, W. W.) 68–73 (University of St Andrews Press, Edinburgh, 1965).

    Google Scholar 

  24. Slamon, D. J., Müller, R., Cline, M. J. & Verma, I. M. Science (submitted).

  25. Comings, D. E. Proc. natn. Acad. Sci. U.S.A. 70, 3324–3328 (1973).

    Article  ADS  CAS  Google Scholar 

  26. Bishop, J. M. ICN-UCLA Symp. molec. cell. Biol. 23, 515–524 (1981).

    CAS  Google Scholar 

  27. Chirgwin, J. M., Pryzybala, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294–5299 (1979).

    Article  CAS  PubMed  Google Scholar 

  28. Aviv, H. & Leder, P. Proc. natn. Acad. Sci. U.S.A. 69, 1408–1412 (1972).

    Article  ADS  CAS  Google Scholar 

  29. Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977).

    Article  CAS  PubMed  Google Scholar 

  30. Jones, M. et al. Proc. natn. Acad Sci. U.S.A. 77, 2651–2655 (1980).

    Article  ADS  CAS  Google Scholar 

  31. Goff, S. P., Gilboa, E., Witte, O. N. & Baltimore, D. Cell 22, 777–785 (1980).

    Article  CAS  PubMed  Google Scholar 

  32. Ellis, R. W. et al. J. Virol. 36, 408–420 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Tilghman, S. M. et al. J. biol. Chem. 254, 7393–7399 (1979).

    CAS  PubMed  Google Scholar 

  34. Wilson, J. R. & Zimmerman, E. F. Devl Biol. 54, 187–200 (1976).

    Article  CAS  Google Scholar 

  35. Dziadek, M. & Adamson, E. J. Embryol. exp. Morphol. 143, 289–313 (1978).

    Google Scholar 

  36. Thomas, P. .S Proc. natn. Acad. Sci. U.S.A. 77, 5201–5205 (1980).

    Article  ADS  CAS  Google Scholar 

  37. Raschke, W. Cold Spring Harb Symp. quant. Biol. 44, 1187–1194 (1979).

    Article  Google Scholar 

  38. Scher, C. D. & Siegler, R. Nature 253, 729–731 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  39. Maisel, J., Scolnick, E. M. & Duesberg, P. H. J. Virol. 16, 749–753 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Tumor Virology Laboratory, The Salk Institute, PO Box 85800, San Diego, California, 92138, USA

    Rolf Müller, Joanne M. Tremblay & Inder M. Verma

  2. Division of Hematology/Oncology, Department of Medicine, UCLA Medical Center, Los Angeles, California, 92004, USA

    Dennis J. Slamon & Martin J. Cline

Authors
  1. Rolf Müller
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  2. Dennis J. Slamon
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  3. Joanne M. Tremblay
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  4. Martin J. Cline
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  5. Inder M. Verma
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Müller, R., Slamon, D., Tremblay, J. et al. Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature 299, 640–644 (1982). https://doi.org/10.1038/299640a0

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