Abstract
The sequence of the highly polymorphic region near the human insulin gene, which begins 363 base pairs before the start of transcription and extends upstream, indicated that it is generated by variation in the number and arrangement of members of a family of tandemly repeating nucleotides whose structure is related to ACAGGGGTGTGGGG. Another 15-base pair sequence, repeated twice near the human gene, is located ∼325 base pairs on either side of the polymorphic region. One member is in the transcriptional control region.
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Bell, G., Selby, M. & Rutter, W. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature 295, 31–35 (1982). https://doi.org/10.1038/295031a0
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DOI: https://doi.org/10.1038/295031a0
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