Abstract
THE specificity of human smooth muscle autoantibodies (SMA) is known only in chronic active hepatitis where SMA are of anti-actin type1,2. In other diseases there seem to be SMA of additional specificities3–5. Anti-actin antibodies react with microfilaments of cultured cells6,7. We describe here two human SMA-positive sera which react in indirect immunofluorescence microscopy (IFL) with other cytoskeletal structures, intermediate (100 Å) filaments. Such filaments are especially abundant in smooth muscle cells8,9 but occur also in other cells including fibroblasts10.
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KURKI, P., LINDER, E., VIRTANEN, I. et al. Human smooth muscle autoantibodies reacting with intermediate (100 Å) filaments. Nature 268, 240–241 (1977). https://doi.org/10.1038/268240a0
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DOI: https://doi.org/10.1038/268240a0
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