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Mechanism for suppression of cellular biosynthesis of prostaglandins

Nature volume 260, pages 630–632 (1976)Cite this article

Abstract

BIOSYNTHESIS of prostaglandins (PGs) from unsaturated fatty acid precursors involves a complex sequence of reactions that seem to proceed rapidly in response to physiological stimuli. Studies in vitro have revealed a capacity for biosynthesis greater than would be expected from measures of tissue content1,2 or daily prostaglandin (PG) production3. Biosynthesis requires release of esterified precursor from tissue lipids4,5, and control of the hydrolytic event may be a major means of controlling PG biosynthesis (for example, in brain6 or spleen7). Another possible type of regulation is control of cyclo-oxygenase activity. Many chemical agents have been examined as modifiers of the PG-forming oxygenase (for example, reviews in refs 8 and 9). The enzyme can be inhibited by fatty acids10 although they appear only in limited amounts in the cytosol. In addition, inhibition of the oxygenation reaction has been observed in vitro with added glutathione peroxidase (GSP) and reduced glutathione (GSH)11–14. We have further investigated this form of enzymatic regulation, and propose that it inhibits by destroying an essential activator of the oxygenase which forms the PGs and thromboxanes.

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Authors and Affiliations

  1. Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 41809

    H. W. COOK & W. E. M. LANDS

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  1. H. W. COOK
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  2. W. E. M. LANDS
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COOK, H., LANDS, W. Mechanism for suppression of cellular biosynthesis of prostaglandins. Nature 260, 630–632 (1976). https://doi.org/10.1038/260630a0

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