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Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse

Nature volume 259, pages 665–667 (1976)Cite this article

Abstract

THE X linkage of loci coding for glucose-6-phosphate de-hydrogenase (G6PD), hypoxanthine-phosphoribosyl transferase (HPRT), and phosphoglycerate kinase (PGK) has been determined for the mouse species Mus musculus and M. caroli. Evidence was obtained from a somatic cell genetic analysis of cultured embryonic cells of an interspecific hybrid foetus. The X-chromosomal assignment of these loci has been determined already for several other mammalian species. This evidence was obtained from genetic analyses of electrophoretic variants1 and enzyme deficiencies2,3; from the expression of these genes in viable interspecific hybrids4–6; from somatic cell genetic analyses of heterozygotes7–9, and from the expression of these loci in interspecific somatic cell hybrids10.

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Authors and Affiliations

  1. New York State Department of Health, Roswell Park Memorial Institute, Buffalo, New York, 14263

    V. M. CHAPMAN & T. B. SHOWS

Authors
  1. V. M. CHAPMAN
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  2. T. B. SHOWS
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CHAPMAN, V., SHOWS, T. Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse. Nature 259, 665–667 (1976). https://doi.org/10.1038/259665a0

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