Abstract
ALTERATIONS in the permeability of the surface membrane might play a key role in the control of DNA synthesis and cell division1–3. Evidence that changes in hexose transport might participate in growth control comes from reports that uptake of certain hexoses (1) increases after transformation by tumour viruses4–6, and correlates with the expression of the transformed phenotype7; (2) decreases when untransformed fibroblasts reach a density-inhibited monolayer5,8, and (3) rapidly increases after initiating cell division with serum or other agents8,9. We now report, however, that increased hexose transport and initiation of proliferation can be uncoupled in density-inhibited 3T3 mouse fibroblasts. Levels of cortisol which initiate DNA synthesis and division of these cells10,11 actually decrease hexose transport. In addition, some serum components increase hexose transport without initiating proliferation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pardee, A. B., Natn. Cancer Inst. Monogr., 14, 7–20 (1964).
Wallach, D. F. H., Proc. natn. Acad. Sci. U.S.A., 61, 868–874 (1964).
Holley, R. W., Proc. natn. Acad. Sci. U.S.A., 69, 2840–2841 (1972).
Isselbacher, K. J., Proc. natn. Acad. Sci. U.S.A., 69, 585–589 (1972).
Weber, M. J., J. biol. Chem., 248, 2978–2983 (1973).
Hatanaka, M., Biochim. biophys. Acta, 355, 77–104 (1974).
Martin, G. S., Venuta, S., Weber, M., and Rubin, H., Proc. natn. Acad. Sci. U.S.A., 68, 2739–2741 (1971).
Sefton, B. M., and Rubin, H., Proc. natn. Acad. Sci. U.S.A., 68, 3154–3157 (1971).
Vaheri, A., Ruoslahti, E., and Nording, S., Nature new Biol., 238, 211–212 (1972).
Thrash, C. R., and Cunningham, D. D., Nature, 242, 399–401 (1973).
Cunningham, D. D., Thrash, C. R., and Glynn, R. D., in Control of proliferation in animal cells (edit. by Clarkson, B., and Baserga, R.), 105–113 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1974).
Cunningham, D. D., J. biol. Chem., 247, 2464–2470 (1972).
Munck, A., J. biol. Chem., 243, 1039–1042 (1968).
Rosen, J. M., Fina, J. J., Milholland, R. J., and Rosen, F., Cancer Res., 32, 350–355 (1972).
Gazdar, A., Hatanaka, M., Herberman, R., Russell, E., and Ikawa, Y., Proc. Soc. exp. biol. Med., 141, 1044–1050 (1972).
Rubin, H., and Fodge, D., in Control of proliferation in animal cells (edit. by Clarkson, B., and Baserga, R.), 801–816 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1974).
Cunningham, D. D., and Pardee, A. B., Proc. natn. Acad. Sci. U.S.A., 64, 1049–1056 (1969).
De Asua, L. J., Rosengurt, E., and Dulbeco, R., Proc. natn. Acad. Sci. U.S.A., 71, 96–98 (1974).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
THRASH, C., CUNNINGHAM, D. Dissociation of increased hexose transport from initiation of fibroblast proliferation. Nature 252, 45–47 (1974). https://doi.org/10.1038/252045a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/252045a0
This article is cited by
-
Metabolic iteration, evolution and cognition in cellular proliferation
Experientia (1987)
-
Modulation of mammalian cell growth by a choline analog,N-isopropylethanolamine
In Vitro (1982)
-
d-glucose uptake in human liver cell cultures
In Vitro (1981)
-
Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts
Nature (1980)
-
Cell cycle regulation by growth factors and nutrients in normal and transformed cells
In Vitro (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.