Abstract
ANALGESIC doses of morphine change the levels1,2 and release3,4 of acetylcholine from the central nervous system. At the single neurone level, however, little is known of the effects of morphine on cholinergic transmission. On the only central neurones known to receive cholinergic endings, the Renshaw cells5, morphine administered electrophoretically from micropipettes has been shown to modify cell activity in several ways; to reduce the depressant action of glycine6, to increase the latency of action potentials evoked by a ventral root stimulus7 and to excite7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Howes, J. F., Harris, L. S., Dewey, W. L., and Voyda, C., J. Pharmac., 169, 23–28 (1969).
Crossland, J., and Slater, P., Br. J. Pharmac., 33, 42–47 (1968).
Jhamandas, K., Pinsky, C., and Phillis, J. W., Nature, 228, 176–177 (1970).
Mullin, M. J., Phillis, J. W., and Pinsky, C., Eur. J. Pharmac., 22, 117–119 (1973).
Curtis, D. R., and Ryall, R. W., Expl Brain Res., 2, 81–96 (1966).
Curtis, D. R., and Duggan, A. W., Agents Actions, 1, 14–19 (1969).
Duggan, A. W., and Curtis, D. R., Neuropharmac., 11, 189–196 (1972).
Martin, W. R., Pharmac. Rev., 19, 463–521 (1967).
Blumberg, H., Dayton, H. B., George, M., and Rapaport, D. N., Fedn Proc., 20, 311 (1961).
Curtis, D. R., Phillis, J. W., and Watkins, J. C., J. Physiol. Lond., 150, 656–682 (1960).
Dostrovsky, J., and Pomeranz, B., Nature new Biol., 246, 222–224 (1973).
Curtis, D. R., and Phillis, J. W., J. Physiol., Lond., 153, 17–34 (1960).
Simon, E. J., and Rosenberg, P., J. Neurochem., 17, 881–887 (1970).
Pert, C. B., and Snyder, S. H., Science, 179, 1011–1014 (1973).
Bradley, P. B., and Dray, A., Br. J. Pharmac., 47, 642P (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAVIES, J., DUGGAN, A. Opiate agonist-antagonist effects on Renshaw cells and spinal interneurones. Nature 250, 70–71 (1974). https://doi.org/10.1038/250070a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/250070a0
This article is cited by
-
Characterization of nociceptin hyperalgesia and allodynia in conscious mice
British Journal of Pharmacology (1997)
-
Stimulatory effects of opioids on transmitter release and possible cellular mechanisms: Overview and original results
Neurochemical Research (1996)
-
Substance P and opiate receptors
Nature (1977)
-
Specific action of narcotics on reflex activation of rat alpha-motoneurones
Naunyn-Schmiedeberg's Archives of Pharmacology (1977)
-
Effects of enkephalin and morphine on Renshaw cells in feline spinal cord
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
