Abstract
CERVICAL carcinoma has been correlated with previous infection with herpes simplex virus type 2 detected serologically1–3. These tests have, however, been confused by the fact that type 1 and type 2 herpes simplex viruses cross neutralise and it is therefore difficult to use the data to provide clear evidence for previous type 2 infection4. We have previously shown that antisera to types 1 and 2 viruses contain antibodies to a structural antigen, Band II (ref. 5), which neutralise both types of virus6. By indirect absorption methods, we have shown that they also contain antibodies to type-specific proteins which neutralise the homologous type only6.
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References
Rawls, W. E., Laurel, D., Melnick, J. L., Glicksman, J. M., and Kaufman, R. H., Am. J. Epidemiol., 87, 647 (1968).
Nahmias, A. J., Josey, W. W., Naib, Z.M., Luce, C. F., and Duffey, A., Am. J. Epidemiol., 91, 539 (1970).
Skinner, G. R. B., Thouless, M. E., and Jordan, J. A., J. Obst. Gynec., 78, 1031 (1971).
Wildy, P., Cancer Res., 33, 1465 (1973).
Watson, D. H., and Wildy, P., J. gen. Virol., 4, 163 (1969).
Sim, C., and Watson, D. H., J. gen. Virol., 19, 217 (1973).
Watson, D. H., J. gen. Virol, 4, 151 (1969).
Spear, P., and Roizman, B., J. Virol., 9, 143 (1972).
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POWELL, K., BUCHAN, A., SIM, C. et al. Type-specific protein in herpes simplex virus envelope reacts with neutralising antibody. Nature 249, 360–361 (1974). https://doi.org/10.1038/249360a0
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DOI: https://doi.org/10.1038/249360a0
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