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Increase in Histamine Receptors on Thymus-derived Effector Lymphocytes during the Primary Immune Response to Alloantigens

Nature volume 244, pages 284–287 (1973)Cite this article

Abstract

THE cytolysis of alloantigen-bearing target cells by thymus-derived (T) lymphocytes from appropriately immunized animals has particular relevance to allograft rejection (see ref. 1 for review). Although the mechanism of lysis remains imperfectly understood, recent studies suggest that it consists of multiple steps2–4 triggered by antigen-lymphocyte interaction5, which terminate in the secretion of a cytotoxic mediator protein into or onto the membrane of the target cell6,7.

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Authors and Affiliations

  1. Department of Medicine, Johns Hopkins University School of Medicine and O'Neill Memorial Research Laboratories, Baltimore, Maryland, 21239

    MARSHALL PLAUT, LAWRENCE M. LICHTENSTEIN & CHRISTOPHER S. HENNEY

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  1. MARSHALL PLAUT
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  2. LAWRENCE M. LICHTENSTEIN
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  3. CHRISTOPHER S. HENNEY
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PLAUT, M., LICHTENSTEIN, L. & HENNEY, C. Increase in Histamine Receptors on Thymus-derived Effector Lymphocytes during the Primary Immune Response to Alloantigens. Nature 244, 284–287 (1973). https://doi.org/10.1038/244284a0

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