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Granules Containing Lead in Isolated Mitochondria

Nature volume 243, pages 100–101 (1973)Cite this article

Abstract

THE divalent cations of calcium, strontium, manganese, barium and magnesium can accumulate in mitochondria1. In spite of variations in rates and in requirements for chemical components of the incubation medium, uptake of these cations leading to granule formation is dependent on energy1. We report here the accumulation of lead in granules produced in isolated rat liver mitochondria following incubation in media containing lead. The computed levels of free lead ion in the media ranged from 0.2 µmol to 100 µmol; by comparison, total plasma lead levels of up to 8 µmol have been found in victims of lead poisoning2.

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Authors and Affiliations

  1. Department of Experimental Pathology, The John Curtin School of Medical Research, The Australian National University, Box 4, GPO, Canberra, ACT

    J. R. WALTON

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  1. J. R. WALTON
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WALTON, J. Granules Containing Lead in Isolated Mitochondria. Nature 243, 100–101 (1973). https://doi.org/10.1038/243100a0

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