Abstract
THE usefulness of the theta (θ) alloantigen as a marker for thymus-derived lymphocytes in mice1–6 has emphasized the need for a distinguishing marker for thymus-independent (bone marrow-derived) lymphocytes, about which relatively little is known. We have raised an antiserum in a rabbit against lymph node cells from mice which had been thymectomized, irradiated and reconstituted with foetal liver cells, which after appropriate absorption was cytotoxic only to those lymphoid cells which were thymus-independent. Because the cell surface antigen(s) with which the antiserum is principally reacting seems to be species-specific, we have followed the example of Shigeno et al.7 and have called it MBLA (mouse-specific bone marrow-derived lymphocyte antigen).
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RAFF, M., NASE, S. & MITCHISON, N. Mouse Specific Bone Marrow-derived Lymphocyte Antigen as a Marker for Thymus-independent Lymphocytes. Nature 230, 50–51 (1971). https://doi.org/10.1038/230050a0
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DOI: https://doi.org/10.1038/230050a0
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