Abstract
THE infection of confluent cultures of “permissive” cells by polyoma virus promotes a sharp increase in the rate of cellular DNA synthesis1–3 in the cells in which the production of virus eventually takes place4. It is also known from investigations carried out with viral mutants that the induction of DNA synthesis in the host cells does not require viral DNA replication5,6. Nevertheless it is known from inactivation experiments that the stimulation of cellular DNA synthesis is a function of the viral genome, although the processes involved at the molecular level remain rather obscure4,7,8. In systems of cells where multiplication is controlled by population density, viral infection with either polyoma or SV40 releases cells from contact inhibition. DNA synthesis does not shift to an uncontrolled level; only the block between the G1 and the S phases in resting cells seems to be removed8. Several other physiological or artificial states, notably that resulting from differentiation in which cell DNA synthesis is suppressed, can be overcome by infection with such viruses8,9. In any case the extent of stimulation seems to reach an absolute limit in the normal rate of cellular DNA replication during exponential growth.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dulbecco, R., Hartwell, L. H., and Vogt, M., Proc. US Nat. Acad. Sci., 53, 403 (1965).
Weil, R., Michel, M. R., and Ruschmann, G. K., Proc. US Nat. Acad. Sci., 53, 1468 (1965).
Winocour, E., Kaye, A. M., and Stollar, V., Virology, 27, 156 (1965).
Basilico, C., Marin, G., and Di Mayorca, G., Proc. US Nat. Acad. Sci., 56, 208 (1966).
Eckhart, W., Virology, 38, 120 (1969).
Di Mayorca, G., Callender, J., and Giordano, R., Virology, 38, 126 (1969).
Gershon, D., Hausen, P., Sachs, L., and Winocour, E., Proc. US Nat. Acad. Sci., 54, 1584 (1965).
Winocour, E., Adv. Vir. Res., 14, 153 (1969).
Yaffe, D., and Gershon, D., Nature, 215, 421 (1967).
Basilico, C., Matsuya, Y., and Green, H., J. Virol., 3, 139 (1969).
Todaro, G., Matsuya, Y., Bloom, S., Robbins, A., and Green, H., Wistar Symp. Monogr., 7, 87 (1967).
Vesco, C., and Penman, S., Biochem. Biophys. Res. Commun., 35, 249 (1969).
Radloff, R., Bauer, W., and Vinograd, J., Proc. US Nat. Acad. Sci., 57, 1514 (1967).
Borst, P., Van Bruggen, E. F. J., Ruttenberg, G. J., and Kroon, A. M., Biochim. Biophys. Acta, 149, 156 (1967).
Nass, M. M. K., Science, 165, 25 (1969).
Levine, A., Proc. US Nat. Acad. Sci. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
VESCO, C., BASILICO, C. Induction of Mitochondrial DNA Synthesis by Polyoma Virus. Nature 229, 336–338 (1971). https://doi.org/10.1038/229336a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/229336a0
This article is cited by
-
Human cytomegalovirus infection of WI-38 cells stimulates mitochondrial DNA synthesis
Nature (1976)
-
Über eine anhaltende Hemmung der Zellproliferation durch onkogenes Polyomavirus bei Ratten
Virchows Archiv B Cell Pathology (1974)
-
Mitochondrial DNA synthesis in Raji cells infected by herpes simplex virus or Epstein-Barr virus
Medical Microbiology and Immunology (1973)
-
Ultrastrukturveränderungen des Harding-Passey-Melanoms durch Übertragung auf xenogene Wirte
Archiv für Dermatologische Forschung (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.